The role of interferon regulatory factors in non-alcoholic fatty liver disease and non-alcoholic steatohepatitis

C Zhang, S Liu, M Yang - Gastroenterology Insights, 2022 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is becoming the most common chronic liver
disease with many metabolic comorbidities, such as obesity, diabetes, and cardiovascular …

The role of IFN in the development of NAFLD and NASH

M Møhlenberg, E Terczynska-Dyla, KL Thomsen… - Cytokine, 2019 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) and its progressive inflammatory form non-
alcoholic steatohepatitis (NASH) are major health challenges due to a significant increase in …

[HTML][HTML] IL-1 cytokine family members and NAFLD: neglected in metabolic liver inflammation

H Tilg, AR Moschen - Journal of hepatology, 2011 - journal-of-hepatology.eu
Nonalcoholic fatty liver disease (NAFLD) is a major cause of liver disease throughout the
world [1]. It is currently considered as the hepatic manifestation of metabolic syndrome and …

The presence of interferon affects the progression of non-alcoholic fatty liver disease

M Møhlenberg, PL Eriksen, TL Laursen, MB Nielsen… - Genes & …, 2022 - nature.com
Inflammation and metabolic dysfunction are hallmarks of the progression of non-alcoholic
fatty liver disease (NAFLD), which is the fastest-growing liver disease worldwide. Emerging …

Regulatory Networks, Management Approaches, and Emerging Treatments of Nonalcoholic Fatty Liver Disease

B Yang, X Yang, X Tan, L Lu, W Fan… - Canadian Journal of …, 2022 - Wiley Online Library
The pathogenesis of NAFLD is complex and diverse, involving multiple signaling pathways
and cytokines from various organs. Hepatokines, stellakines, adipokines, and myokines …

[HTML][HTML] Hepatocyte nuclear factor 1A suppresses innate immune response by inducing degradation of TBK1 to inhibit steatohepatitis

J He, C Du, X Peng, W Hong, D Qiu, X Qiu, X Zhang… - Genes & …, 2023 - Elsevier
Abstract Non-alcoholic steatohepatitis (NASH), a progressive form of non-alcoholic fatty liver
disease (NAFLD), is characterised by chronic liver inflammation, which can further progress …

Overexpression of interleukin-8 promotes the progression of fatty liver to nonalcoholic steatohepatitis in mice

YE Cho, Y Kim, SJ Kim, H Lee, S Hwang - International Journal of …, 2023 - mdpi.com
Nonalcoholic steatohepatitis (NASH) is an advanced stage of fatty liver disease
characterized by liver damage, inflammation, and fibrosis. Although neutrophil infiltration is …

IFN-γ contributes to the hepatic inflammation in HFD-induced nonalcoholic steatohepatitis by STAT1β/TLR2 signaling pathway

J Li, Q Chen, J Yi, X Lan, K Lu, X Du, Z Guo, Y Guo… - Molecular …, 2021 - Elsevier
Growing research evidence suggests that elevated TLR2 is closely related to the occurrence
and development of nonalcoholic steatohepatitis (NASH). However, a little is known about …

[HTML][HTML] Emerging novel targets for nonalcoholic fatty liver disease treatment: Evidence from recent basic studies

GY Wang, XY Zhang, CJ Wang… - World Journal of …, 2023 - ncbi.nlm.nih.gov
Nonalcoholic fatty liver disease (NAFLD), a leading chronic disease worldwide, affects
approximately a quarter of the global population. Nonalcoholic steatohepatitis (NASH) is an …

Adipose type I interferon signalling protects against metabolic dysfunction

V Wieser, TE Adolph, C Grander, F Grabherr, B Enrich… - Gut, 2018 - gut.bmj.com
Objective Low-grade chronic inflammation emerges as a potent driver of insulin resistance
and glucose dysregulation in obesity and associated non-alcoholic fatty liver disease …