Protein kinases, a class of enzymes that govern various biological phenomena at a cellular
level, are responsible for signal transduction in cells that regulate cellular proliferation …

Tyrosine kinases (TKs) are a large subfamily of the largest known gene family, the kinases,
of which the human genome is now estimated to contain in excess of 2,000 [1]. TKs catalyse …

Kinase inhibitors are a significant and continuously developing division of target
therapeutics. The drug discovery and improvement efforts have examined numerous …

Receptor and non-receptor protein tyrosine kinases (PTKs) are essential enzymes in cellular
signaling processes and signal transduction pathways that regulate cell growth …

Cancer is one of the leading causes of death with a mortality rate of 12%. Although
significant progress has been achieved in cancer research, the effective treatment of cancer …

Protein phosphorylation is one of the major pathways used by eukaryotic cells to propagate
signals to the final effectors, regulating multiple aspects of the living cell, such as …

Cancer chemotherapy has been one of the major medical advances in the last few decades.
However, the drugs used for this therapy have a narrow therapeutic index, and often the …

Tyrosine kinase inhibitors are taking up an increasingly significant role in treating cancers.
There are different types of TKIs currently used in clinical settings. However, TKI-associated …

Cancer chemotherapy has been one of the major medical advances in the last few decades.
However, the drugs used for this therapy have a narrow therapeutic index, and often the …

Cancer is the second leading cause of death in the western world. Despite advances in
diagnosis and treatment, overall survival of patients remains poor. Scientific advances in …