Platelet glycoprotein (GP) VI is a promising, safe, antithrombotic target as its absence or
blockade prevents in vitro thrombus formation and experimental thrombosis in various …

Objective: GPVI (glycoprotein VI) is a key molecular player in collagen-induced platelet
signaling and aggregation. Recent evidence indicates that it also plays important role in …

Despite significant advances in the treatment of thrombogenic diseases, antiplatelet
therapies are still associated with a high bleeding risk. Consequently, potential benefits of …

Platelet glycoprotein VI (GPVI) acts as a decisive collagen receptor in atherothrombosis.
Besides collagen, injured atherosclerotic plaques expose tissue factor (TF) that triggers …

Platelets play a central role in arrest of bleeding. The ability of platelets to engage with
extracellular matrix proteins of the subendothelium has long been recognised as a pivotal …

Glycoprotein VI (GPVI) is an activating receptor expressed on the surface of platelets and
megakaryocytes. Clustering of GPVI upon collagen binding triggers a signaling cascade that …

Fibrin, the coagulation end product, consolidates the platelet plug at sites of vascular injury
and supports the recruitment of circulating platelets. In addition to integrin αIIbβ3, another as …

Glycoprotein VI (GPVI) is a membrane glycoprotein unique to platelets and has been
identified as a physiological receptor for collagen. Damage to a vessel wall exposes the …

Glycoprotein (GP) VI is a platelet membrane protein with a molecular weight of 62 kDa that
was identified as a physiological collagen receptor from studies of patients deficient in this …

Platelet—collagen interactions play a fundamental role in the process of arterial thrombosis.
The major platelet collagen receptor is the glycoprotein VI (GPVI). Here, we determined the …