A guide to plasma membrane solute carrier proteins

MD Pizzagalli, A Bensimon… - The FEBS …, 2021 - Wiley Online Library
This review aims to serve as an introduction to the solute carrier proteins (SLC) superfamily
of transporter proteins and their roles in human cells. The SLC superfamily currently …

Analysis and update of the human solute carrier (SLC) gene superfamily

L He, K Vasiliou, DW Nebert - Human genomics, 2009 - Springer
The solute-carrier gene (SLC) superfamily encodes membrane-bound transporters. The
SLC superfamily comprises 55 gene families having at least 362 putatively functional protein …

A call for systematic research on solute carriers

A Cesar-Razquin, B Snijder, T Frappier-Brinton… - Cell, 2015 - cell.com
Solute carrier (SLC) membrane transport proteins control essential physiological functions,
including nutrient uptake, ion transport, and waste removal. SLCs interact with several …

SLC transporters as therapeutic targets: emerging opportunities

L Lin, SW Yee, RB Kim, KM Giacomini - Nature reviews Drug discovery, 2015 - nature.com
Solute carrier (SLC) transporters—a family of more than 300 membrane-bound proteins that
facilitate the transport of a wide array of substrates across biological membranes—have …

The druggability of solute carriers

WW Wang, L Gallo, A Jadhav, R Hawkins… - Journal of medicinal …, 2019 - ACS Publications
The transport of materials across membranes is a vital process for all aspects of cellular
function, including growth, metabolism, and communication. Protein transporters are the …

The SLC transporter in nutrient and metabolic sensing, regulation, and drug development

Y Zhang, Y Zhang, K Sun, Z Meng… - Journal of molecular cell …, 2019 - academic.oup.com
The prevalence of metabolic diseases is growing worldwide. Accumulating evidence
suggests that solute carrier (SLC) transporters contribute to the etiology of various metabolic …

Structural biology of solute carrier (SLC) membrane transport proteins

X Bai, TF Moraes, RAF Reithmeier - Molecular membrane biology, 2017 - Taylor & Francis
The human solute carriers (SLCs) comprise over 400 different transporters, organized into
65 families (http://slc. bioparadigms. org/) based on their sequence homology and transport …

[HTML][HTML] Targeted degradation of SLC transporters reveals amenability of multi-pass transmembrane proteins to ligand-induced proteolysis

A Bensimon, MD Pizzagalli, F Kartnig, V Dvorak… - Cell chemical …, 2020 - cell.com
With more than 450 members, the solute carrier (SLC) group of proteins represents the
largest class of transporters encoded in the human genome. Their several-pass …

Classification systems of secondary active transporters

E Perland, R Fredriksson - Trends in pharmacological sciences, 2017 - cell.com
Membrane-bound solute carrier (SLC) transporter proteins are vital to the human body, as
they sustain homeostasis by moving soluble molecule as nutrients, drugs, and waste across …

[HTML][HTML] The ABCs of membrane transporters in health and disease (SLC series): introduction

MA Hediger, B Clémençon, RE Burrier… - Molecular aspects of …, 2013 - Elsevier
The field of transport biology has steadily grown over the past decade and is now
recognized as playing an important role in manifestation and treatment of disease. The SLC …