Fats, friends or foes: investigating the role of short-and medium-chain fatty acids in Alzheimer's disease
Characterising Alzheimer's disease (AD) as a metabolic disorder of the brain is gaining
acceptance based on the pathophysiological commonalities between AD and major …
acceptance based on the pathophysiological commonalities between AD and major …
Potential benefits of medium chain fatty acids in aging and neurodegenerative disease
E Dunn, B Zhang, VK Sahota… - Frontiers in Aging …, 2023 - frontiersin.org
Neurodegenerative diseases are a large class of neurological disorders characterized by
progressive dysfunction and death of neurones. Examples include Alzheimer's disease …
progressive dysfunction and death of neurones. Examples include Alzheimer's disease …
The impact of medium chain and polyunsaturated ω-3-fatty acids on amyloid-β deposition, oxidative stress and metabolic dysfunction associated with Alzheimer's …
J Mett - Antioxidants, 2021 - mdpi.com
Alzheimer's disease (AD), the most common cause of dementia in the elderly population, is
closely linked to a dysregulated cerebral lipid homeostasis and particular changes in brain …
closely linked to a dysregulated cerebral lipid homeostasis and particular changes in brain …
Medium-chain fatty acids for the prevention or treatment of Alzheimer's disease: a systematic review and meta-analysis
Abstract Context In preclinical Alzheimer's disease (AD), the brain gradually becomes
insulin resistant. As a result, brain glucose utilization is compromised, causing a cellular …
insulin resistant. As a result, brain glucose utilization is compromised, causing a cellular …
Fatting the brain: a brief of recent research
G Hussain, F Schmitt, JP Loeffler… - Frontiers in cellular …, 2013 - frontiersin.org
Fatty acids are of paramount importance to all cells, since they provide energy, function as
signaling molecules, and sustain structural integrity of cellular membranes. In the nervous …
signaling molecules, and sustain structural integrity of cellular membranes. In the nervous …
Fatty acid metabolism in the progression and resolution of CNS disorders
JFJ Bogie, M Haidar, G Kooij, JJA Hendriks - Advanced drug delivery …, 2020 - Elsevier
Recent advances in lipidomics and metabolomics have unveiled the complexity of fatty acid
metabolism and the fatty acid lipidome in health and disease. A growing body of evidence …
metabolism and the fatty acid lipidome in health and disease. A growing body of evidence …
Fatty acids and beyond: Age and Alzheimer's disease related changes in lipids reveal the neuro-nutraceutical potential of lipids in cognition
Lipids are essential in maintaining brain function, and lipid profiles have been reported to be
altered in aged and Alzheimer's disease (AD) brains as compared to healthy mature brains …
altered in aged and Alzheimer's disease (AD) brains as compared to healthy mature brains …
Dietary fiber and microbiota metabolite receptors enhance cognition and alleviate disease in the 5xFAD mouse model of Alzheimer's disease
Alzheimer's disease (AD) is a neurodegenerative disorder with poorly understood etiology.
AD has several similarities with other “Western lifestyle” inflammatory diseases, where the …
AD has several similarities with other “Western lifestyle” inflammatory diseases, where the …
Association between fatty acid metabolism in the brain and Alzheimer disease neuropathology and cognitive performance: A nontargeted metabolomic study
SG Snowden, AA Ebshiana, A Hye, Y An… - PLoS …, 2017 - journals.plos.org
Background The metabolic basis of Alzheimer disease (AD) pathology and expression of AD
symptoms is poorly understood. Omega-3 and-6 fatty acids have previously been linked to …
symptoms is poorly understood. Omega-3 and-6 fatty acids have previously been linked to …
Fatty acids and their therapeutic potential in neurological disorders
E Lei, K Vacy, WC Boon - Neurochemistry international, 2016 - Elsevier
There is little doubt that we are what we eat. Fatty acid supplementation and diets rich in fatty
acids are being promoted as ways to a healthier brain. Short chain fatty acids are a product …
acids are being promoted as ways to a healthier brain. Short chain fatty acids are a product …