Characterising Alzheimer's disease (AD) as a metabolic disorder of the brain is gaining
acceptance based on the pathophysiological commonalities between AD and major …

Neurodegenerative diseases are a large class of neurological disorders characterized by
progressive dysfunction and death of neurones. Examples include Alzheimer's disease …

Alzheimer's disease (AD), the most common cause of dementia in the elderly population, is
closely linked to a dysregulated cerebral lipid homeostasis and particular changes in brain …

Abstract Context In preclinical Alzheimer's disease (AD), the brain gradually becomes
insulin resistant. As a result, brain glucose utilization is compromised, causing a cellular …

Fatty acids are of paramount importance to all cells, since they provide energy, function as
signaling molecules, and sustain structural integrity of cellular membranes. In the nervous …

Recent advances in lipidomics and metabolomics have unveiled the complexity of fatty acid
metabolism and the fatty acid lipidome in health and disease. A growing body of evidence …

Lipids are essential in maintaining brain function, and lipid profiles have been reported to be
altered in aged and Alzheimer's disease (AD) brains as compared to healthy mature brains …

Background The metabolic basis of Alzheimer disease (AD) pathology and expression of AD
symptoms is poorly understood. Omega-3 and-6 fatty acids have previously been linked to …

Alzheimer's disease (AD) is a neurodegenerative disorder with poorly understood etiology.
AD has several similarities with other “Western lifestyle” inflammatory diseases, where the …

There is little doubt that we are what we eat. Fatty acid supplementation and diets rich in fatty
acids are being promoted as ways to a healthier brain. Short chain fatty acids are a product …