Despite several recent studies suggesting that dysregulation of brain lipid metabolism might
contribute to the mechanisms of aging and Alzheimer's disease (AD), lipid metabolism has …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that accompanied by
memory deficits and neuropsychiatric dysfunction. Omega-3 polyunsaturated fatty acids (n-3 …

Alzheimer's disease (AD) is a neurodegenerative disease with as yet no efficient therapies,
the pathophysiology of which is still largely unclear. Many drugs and therapies have been …

Alzheimer's disease (AD) is a devastating neurodegenerative disorder currently affecting
over 35 million people worldwide. Pathological hallmarks of AD are massive amyloidosis …

Neurodegenerative disorders are commonly associated with a complex pattern of
pathophysiological hallmarks, including increased oxidative stress and neuroinflammation …

We examined the effect of chronic high fat diet (HFD) on amyloid deposition and cognition of
12-months old APP23 mice, and correlated the phenotype to brain transcriptome and …

Concomitant with increased lifespan, large segments of the population are experiencing
cognitive decline, which might progress to Alzheimer's disease (AD). Currently, there is no …

Dietary polyunsaturated fatty acids (PUFAs) have gained more importance these last
decades since they regulate the level of long-chain PUFAs (LC-PUFAs) in all cells and …

Aging contributes to physiological decline and vulnerability to disease. In the brain, even
with minimal neuronal loss, aging increases oxidative damage, inflammation, demyelination …

Alzheimer's disease (AD) is the most common form of dementia. Currently, there is no
effective medication for the prevention or treatment of AD. This has led to the search for …