Neuroleptic receptor binding in drug research
I Creese, EJ Hess - Receptor binding in drug research, 2020 - taylorfrancis.com
The success of neuroleptic drugs in the treatment of schizophrenia since their introduction in
1952 has initiated much research into the biochemical actions of these antipsychotic agents …
1952 has initiated much research into the biochemical actions of these antipsychotic agents …
Neuroleptic binding sites in brain
SE LEFF, IAN CREESE - Brain Receptor Methodologies, 1984 - Elsevier
Publisher Summary Many researchers now believe that neuroleptic drugs, such as the
phenothiazines, exert their actions in the brains of schizophrenics at sites that are involved …
phenothiazines, exert their actions in the brains of schizophrenics at sites that are involved …
Dopamine receptors and the dopamine hypothesis of schizophrenia
P Seeman - Synapse, 1987 - Wiley Online Library
The discovery of neuroleptic drugs in 1952 provided a new strategy for seeking a biological
basis of schizophrenia. This entailed a search for a primary site of neuroleptic action. The …
basis of schizophrenia. This entailed a search for a primary site of neuroleptic action. The …
Abnormal neuroleptic/dopamine receptors in schizophrenia.
T Lee, P Seeman - Advances in Biochemical Psychopharmacology, 1980 - europepmc.org
In order to test the dopamine hypothesis of schizophrenia, the neuroleptic/dopamine
receptors in three dopamine-rich regions of 53 postmortem normal human brains and 42 …
receptors in three dopamine-rich regions of 53 postmortem normal human brains and 42 …
Biochemical actions of neuroleptic drugs: Focus on the dopamine receptor
I Creese, DR Burt, SH Snyder - Handbook of Psychopharmacology …, 1978 - Springer
Who cares how antipsychotic drugs act? What difference does it make whether the clinical
effects of neuroleptics derive from one or another biochemical influence? Such questions …
effects of neuroleptics derive from one or another biochemical influence? Such questions …
[PDF][PDF] Elevation of brain neuroleptic/dopamine receptors in schizophrenia
P Seeman, T Lee, ED Bird… - Perspectives in …, 1980 - researchgate.net
The antidopaminergic actions of the neuroleptic drugs provide a strategy for searching for
dopaminergic abnormalities in schizophrenia brain tissue. In order to test the dopamine …
dopaminergic abnormalities in schizophrenia brain tissue. In order to test the dopamine …
Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs.
I Creese, DR Burt, SH Snyder - The Journal of neuropsychiatry and …, 1996 - europepmc.org
Tritiated haloperidol and tritiated dopamine label postsynaptic dopamine receptors in
mammalian brain. Clinical potencies of butyrophenones, phenothiazines, and related drugs …
mammalian brain. Clinical potencies of butyrophenones, phenothiazines, and related drugs …
Dopamine receptor changes in schizophrenia in relation to the disease process and movement disorder
AJ Cross, TJ Crow, IN Ferrier, EC Johnstone… - Basic Aspects of …, 1983 - Springer
Although dopamine receptor antagonism probably accounts for the therapeutic efficacy of
neuroleptic drugs in schizophrenia, there is little evidence to suggest that dopamine …
neuroleptic drugs in schizophrenia, there is little evidence to suggest that dopamine …
Relationship of neuroleptic drug effects at brain dopamine, serotonin, alpha-adrenergic, and histamine receptors to clinical potency.
SJ Peroutka, SH Synder - The American journal of psychiatry, 1980 - europepmc.org
The authors examined the potencies of 22 neuroleptic drugs competing for binding sites
associated with dopamine, serotonin, alpha-adrenergic, and histamine receptors in brain …
associated with dopamine, serotonin, alpha-adrenergic, and histamine receptors in brain …