Oncolytic viruses, effectively replicate viruses within malignant cells to lyse them without
affecting normal ones, have recently shown great promise in developing therapeutic options …

Oncolytic adenovirus (Ad) has been used in cancer gene therapy largely due to its ability to
selectively infect and replicate in tumor cells. However, because the oncolytic antitumor …

Despite promising results in preclinical studies, the therapeutic efficacy of oncolytic
adenoviruses (Ads) has not been reproduced in clinical trials in patients with cancer. Recent …

Highlights•Oncolytic adenoviruses (Onc. Ads) are promising as cancer gene therapy
agents.•Onc. Ad selectivity and cytolytic potency can be enhanced by genetic …

Adenovirus (Ad) has been most extensively evaluated gene transfer vector in clinical trials
due to facile production in high viral titer, highly efficient transduction, and proven safety …

Oncolytic adenovirus (Ad) vectors present a new modality to treat cancer. These vectors
attack tumors via replicating in and killing cancer cells. Upon completion of the vector …

Cancer is a major health problem. Most of the treatments exhibit systemic toxicity, as they
are not targeted or specific to cancerous cells and tumors. Adenoviruses are very promising …

Cancer therapy using oncolytic viruses is an emerging area, in which viruses are
engineered to selectively propagate in tumor tissues without affecting healthy cells. Because …

Oncolytic adenoviruses (Ads) constitute a promising new class of anticancer agent. They are
based on the well-studied adenoviral vector system, which lends itself to concept-driven …

Oncolytic adenovirus (OAds) has long been considered a promising biotherapeutic agent
against various types of cancer owing to selectively replicate in and lyse cancer cells, while …