Strategies for enhancing intratumoral spread of oncolytic adenoviruses
NH Goradel, B Negahdari, S Ghorghanlu… - Pharmacology & …, 2020 - Elsevier
Oncolytic viruses, effectively replicate viruses within malignant cells to lyse them without
affecting normal ones, have recently shown great promise in developing therapeutic options …
affecting normal ones, have recently shown great promise in developing therapeutic options …
Evolution of oncolytic adenovirus for cancer treatment
JW Choi, JS Lee, SW Kim, CO Yun - Advanced drug delivery reviews, 2012 - Elsevier
Oncolytic adenovirus (Ad) has been used in cancer gene therapy largely due to its ability to
selectively infect and replicate in tumor cells. However, because the oncolytic antitumor …
selectively infect and replicate in tumor cells. However, because the oncolytic antitumor …
Anatomical and physical barriers to tumor targeting with oncolytic adenoviruses in vivo.
Despite promising results in preclinical studies, the therapeutic efficacy of oncolytic
adenoviruses (Ads) has not been reproduced in clinical trials in patients with cancer. Recent …
adenoviruses (Ads) has not been reproduced in clinical trials in patients with cancer. Recent …
Recent advances in oncolytic adenovirus therapies for cancer
AR Shaw, M Suzuki - Current opinion in virology, 2016 - Elsevier
Highlights•Oncolytic adenoviruses (Onc. Ads) are promising as cancer gene therapy
agents.•Onc. Ad selectivity and cytolytic potency can be enhanced by genetic …
agents.•Onc. Ad selectivity and cytolytic potency can be enhanced by genetic …
[HTML][HTML] Overcoming the limitations of locally administered oncolytic virotherapy
JW Hong, CO Yun - BMC Biomedical Engineering, 2019 - Springer
Adenovirus (Ad) has been most extensively evaluated gene transfer vector in clinical trials
due to facile production in high viral titer, highly efficient transduction, and proven safety …
due to facile production in high viral titer, highly efficient transduction, and proven safety …
Increasing the efficacy of oncolytic adenovirus vectors
K Toth, WSM Wold - Viruses, 2010 - mdpi.com
Oncolytic adenovirus (Ad) vectors present a new modality to treat cancer. These vectors
attack tumors via replicating in and killing cancer cells. Upon completion of the vector …
attack tumors via replicating in and killing cancer cells. Upon completion of the vector …
[HTML][HTML] Oncolytic adenoviruses: strategies for improved targeting and specificity
Cancer is a major health problem. Most of the treatments exhibit systemic toxicity, as they
are not targeted or specific to cancerous cells and tumors. Adenoviruses are very promising …
are not targeted or specific to cancerous cells and tumors. Adenoviruses are very promising …
Oncolytic adenovirus: A tool for cancer therapy in combination with other therapeutic approaches
NH Goradel, N Mohajel, ZV Malekshahi… - Journal of cellular …, 2019 - Wiley Online Library
Cancer therapy using oncolytic viruses is an emerging area, in which viruses are
engineered to selectively propagate in tumor tissues without affecting healthy cells. Because …
engineered to selectively propagate in tumor tissues without affecting healthy cells. Because …
[HTML][HTML] Current issues and future directions of oncolytic adenoviruses
M Yamamoto, DT Curiel - Molecular Therapy, 2010 - cell.com
Oncolytic adenoviruses (Ads) constitute a promising new class of anticancer agent. They are
based on the well-studied adenoviral vector system, which lends itself to concept-driven …
based on the well-studied adenoviral vector system, which lends itself to concept-driven …
Delivery systems for enhancing oncolytic adenoviruses efficacy
YC Zhou, YN Zhang, X Yang, SB Wang… - International Journal of …, 2020 - Elsevier
Oncolytic adenovirus (OAds) has long been considered a promising biotherapeutic agent
against various types of cancer owing to selectively replicate in and lyse cancer cells, while …
against various types of cancer owing to selectively replicate in and lyse cancer cells, while …