Purpose Heterozygous pathogenic variants in various FOXP genes cause specific
developmental disorders. The phenotype associated with heterozygous variants in FOXP4 …

De novo disruptions of the neural transcription factor FOXP1 are a recently discovered, rare
cause of sporadic intellectual disability (ID). We report three new cases of FOXP1-related …

FOXP1 (forkhead box protein P1) is a transcription factor involved in the development of
several tissues, including the brain. An emerging phenotype of patients with protein …

Background Disruptions of the FOXP2 gene, encoding a forkhead transcription factor, are
the first known monogenic cause of a speech and language disorder. So far, mainly …

Background Heterozygous disruption of FOXP2 causes a rare form of speech and language
impairment. Screens of the FOXP2 sequence in individuals with speech/language-related …

The FOXP subfamily includes four different transcription factors: FOXP1, FOXP2, FOXP3,
and FOXP4, all with important roles in regulating gene expression from early development …

The forkhead box (FOX) transcription factors have roles in development, carcinogenesis,
metabolism, and immunity. In humans FOXP1 mutations have been associated with …

Rare disruptions of FOXP2 have been strongly implicated in deficits in language
development. Research over the past decade has suggested a role in the formation of …

Heterozygous mutations in FOXP2, which encodes a forkhead transcription factor, have
been shown to cause developmental verbal dyspraxia and language impairment. FOXP2 …

FOXP2, the first gene to have been implicated in a developmental communication disorder,
offers a unique entry point into neuromolecular mechanisms influencing human speech and …