Methods This review is based on pertinent publications that were retrieved by a selective
search in PubMed, with special attention to systematic reviews, meta-analyses, and …

Pre-eclampsia has been shown to be associated with platelet activation and excessive
release of vasoconstricting thromboxane preceding the onset of the disease. Low-dose …

Pre-eclampsia is a major contributor to perinatal morbidity and mortality. Large studies of
high-risk pregnant women have shown reduced risk of developing pre-eclampsia when they …

Recent evidence suggests that treatment with low-dose acetylsalicylic acid (ASA) started
early in pregnancy could prevent preeclampsia and intrauterine growth restriction (IUGR) …

Acetylsalicylic acid (ASA) is commonly prescribed prior to 16 weeks of gestation for
prophylaxis of maternal preeclampsia, a condition increasing the risk of delivering preterm …

The use of low-dose aspirin during pregnancy decreases the risk of preeclampsia for
women considered at increased risk. The effect is smaller for women without risk factors …

Objective The objective was to assess the efficacy and safety of low-dose aspirin for the
prevention of preterm birth in nulliparous women. Data sources We searched PubMed …

Background Preeclampsia and fetal growth restriction are major causes of perinatal death
and handicap in survivors. Randomized clinical trials have reported that the risk of …

Objective Data Preconception or early administration of low-dose aspirin might improve
endometrial growth, placental vascularization, and organogenesis. Most studies have …

BACKGROUND: We assessed the effects and safety of aspirin treatment during pregnancy
on fetal and neonatal outcomes. METHODS: We searched MEDLINE (1966–2001) …