The objective of this study was to develop a real-time polymerase chain reaction (PCR)
method to detect MDR1 (human multidrug resistance gene) single nucleotide …

Abstract C1236T, G2677T/A, and C3435T polymorphism of the multidrug resistance (MDR1)
gene have substantial impact on expression or activity of P‐glycoprotein (P‐gp). We …

P-Glycoprotein (PGP) encoded by the multi-drug-resistance 1 (MDR1) gene is a member of
theATP-binding cassette (ABC) transporter family, drug-transporting proteins involved in the …

In vivo and in vitro studies have demonstrated that P-glycoprotein (P-gp) plays a very
significant role in the ADME processes (absorption, distribution, metabolism, excretion) and …

Abstract P-glycoprotein (PGP), the product of the multidrug resistance gene (MDR1), acts as
an energy-dependent efflux pump that exports its substrates out of the cell. PGP expression …

MDR1 (P‐glycoprotein) is an important factor in the disposition of many drugs, and the
involved processes often exhibit considerable interindividual variability that may be …

Two representative genetic variants of the MDR1 gene, 3435C> T and 2677G> T/A, show
wide interethnic differences in its genetic polymorphism. In this study, the authors evaluated …

The multidrug-resistant transporter encoded by the MDR1 gene belongs to the ATP-binding
cassette superfamily of membrane transporters. It is involved not only in the acquisition of …

Drug transporters are increasingly recognized to be important to drug disposition and
response. P‐glycoprotein, the encoded product of the human MDR1 (ABCB1) gene, is of …

The two most frequently observed single nucleotide polymorphisms (SNPs) of the human
multidrug resistance 1 (MDR1) gene are 2677G/T/A (893Ala/Ser/Thr) and 3435C/T (no …