The two most frequently observed single nucleotide polymorphisms (SNPs) of the human
multidrug resistance 1 (MDR1) gene are 2677G/T/A (893Ala/Ser/Thr) and 3435C/T (no …

There exists a marked inter-individual variability of P-glycoprotein expression and activity,
which can be of clinical importance due to the large number of drugs that are substrates for …

The multidrug resistance gene (MDR1 or ABCB1) codes for P-glycoprotein, which plays an
important role in regulating absorption, distribution, and elimination of drugs. We examined …

To determine the relationship between C3435T mutation in exon 26 of the human multidrug
resistant 1 (MDR1) gene and cyclosporine pharmacokinetic parameters among healthy …

The human multidrug resistance gene (MDR1), spanning greater than 200 kb, encodes for
the ATP-dependent membrane efflux transporter, P-glycoprotein (Pgp). Significant progress …

Sumamry Background: P‐glycoprotein (PgP) is the most extensively studied ATP‐binding
cassette (ABC) coded by MDR1 gene. To date, 29 single nucleotide polymorphisms (SNPs) …

Drug transporters are increasingly recognized as a key determinant of drug disposition and
response. The ATP-dependent efflux transporter, MDR1 (P-glycoprotein), has long been …

Human P-glycoprotein (P-gp) is encoded by the MDR1 gene, which is located on
chromosomal region 7q21 and consists of 28 exons. To date, over 50 single nucleotide …

OBJECTIVES: P-glycoprotein (P-gp) is significant from the viewpoint of pharmacokinetics/
pharmacodynamics (PK/PD). MDR1 gene encodes P-gp and has a wide variety of SNPs. As …

The aim of this study was to perform the frequency distribution of MDR1 gene SNPs and
haplotypes of Jiangsu Han population in China. A total of 225 Jiangsu Han unrelated …