P-glycoprotein is an ATP-dependent efflux pump that contributes to the protection of the
body from environmental toxins. It transports a huge variety of structurally diverse …

Resistance to established drugs for cancer therapy is in many cases associated with
overexpression of the multidrug resistance gene 1 (MDR-1). Regulation of basal expression …

Background: It is well recognized that different patients respond in different ways to
medications. The inter-individual variations are greater than the intera-individual variations …

Single nucleotide polymorphisms (SNPs) in the MDR1 gene that are responsible for drug
efflux can cause toxicity. Therefore, this study determined the SNPs of the Korean MDR1 …

Recently, a number of nucleotide variants have been described in the multidrug resistance 1
(MDR1/ABCB1) gene; however, most studies have focused on the coding region. In the …

The prevalent CYP3A5* 3 and the functional multi-drug resistance gene (MDR1) C3435T
show marked interethnic variation among Orientals, Caucasians and Africans. This study …

BACKGROUND: The human multidrug-resistant gene (MDR1) encodes P-glycoprotein
(Pgp), a membrane-bound efflux transporter conferring resistance to a number of natural …

Objective Rheumatoid arthritis (RA) is a multifactorial disease, the pathogenesis of which
involves immunological, genetic and environmental factors. P-glycoprotein (P-gp) encoded …

One of the limitations in the treatment of cancer patients with chemotherapy is the
development of multidrug resistance (MDR). A well-known mechanism responsible for drug …

A recent study with 69 Japanese liver transplants treated with tacrolimus found that the
MDR1 3435 C> T polymorphism, but not the MDR1 2677 G> T polymorphism, was …