Overexpression of P-glycoprotein (P-gp, encoded by MDR1) mediates resistance to multiple
immunosuppressors. Several common MDR1 variants (1236C> T, 2677G> T, 3435C> T) …

The human MDR1 gene encodes MDR1, also called P-glycoprotein (P-gp), which functions
in the energy-dependent export of substances from the inside of cells to the outside. MDR1 …

Objective The P-glycoprotein, a product of MDR1 (multiple drug resistance 1) gene, is a
membrane efflux pump localized in epithelial cells in the small and large intestine, a part of …

Expression levels of P-glycoprotein (P-gp), the transporter encoded by the human multidrug
resistance gene (MDR1), may play an important role in drug disposition. The ability to …

Most drug responses are determined by the interplay of several gene products that influence
pharmacokinetics and pharmacodynamics, ie, drug metabolizing enzymes, drug …

Crohn disease (CD) and ulcerative colitis (UC) are overlapping chronic inflammatory bowel
diseases (IBDs). Suggestive evidence for linkage at chromosome 7q has been reported for …

The significance of the human multidrug resistance gene (MDR1) G1199A polymorphism,
resulting in a Ser400Asn modification in P-glycoprotein (P-gp), remains unclear. We have …

P-glycoprotein (PGP) is a membrane protein which determines drug disposition in humans
(eg digoxin). It is also expressed in various leukocyte lineages with highest expression in …

The three functional single-nucleotide polymorphisms (SNPs) of the MDR1 gene, C1236T,
G2677T/A, and C3435T, exhibit an interpopulation difference. In this study, we analyzed the …

The published data revealed conflicting results of the polymorphism of MDR1 exon 26 SNP
C3435T on the pharmacokinetics of cyclosporine; thus, the aim was to conduct a meta …