The multidrug resistance (MDR1) gene product P-glycoprotein is a membrane bound protein
that functions as an ATP-dependent efflux pump, transporting exogenous and endogenous …

Study of polymorphism in MDR1 gene exons 21 and 26 revealed that T2677T and T3435T
alleles are not a factor predisposing to lymphoproliferative diseases, but they determine the …

The variability of P-glycoprotein expression between individuals is linked to a C3435T
polymorphism of the human MDR1 gene. Concentration of P-glycoprotein in intestinal …

Polymorphisms of the multi drug resistance (MDR1) gene cause variability in P-glycoprotein
mediated metabolism of tacrolimus. The aim of this study was to examine the relationship …

Background. Several single nucleotide polymorphisms (SNPs) in the multidrug resistance
(MDR1) gene may play a role in the interindividual variation of cyclosporine A (CsA) …

The human multidrug resistance gene 1 (MDR1) encodes a plasma membrane, P-
glycoprotein (Pgp), which functions as the transmembrane efflux pump for various …

Background: The frequency of the multi-drug resistance 1 (MDR1) gene C3435T
polymorphism differs in various ethnical populations such as Asian, African, and Caucasians …

The multidrug resistance gene-1 (MDR1, adenosine triphosphate-binding cassette
transporter: ABCB1, P-glycoprotein) encodes membrane proteins that play a crucial role in …

In addition to genetically variable metabolic enzymes such as Cyp p450 proteins, blood and
tissue levels of many drugs are influenced by controlled transport across compartmental …

We assessed whether single nucleotide polymorphisms (SNPs) in MDR1 gene C3435T
predicted the outcome of platinum-based chemotherapies and survival in our non small cell …