Importance The Systolic Blood Pressure Intervention Trial (SPRINT) showed that intensive
blood pressure control reduced cardiovascular morbidity and mortality. However, the legacy …

Background In a previously reported randomized trial of standard and intensive systolic
blood-pressure control, data on some outcome events had yet to be adjudicated and post …

Importance Among high-risk patients with hypertension, targeting a systolic blood pressure
of 120 mm Hg reduces cardiovascular morbidity and mortality compared with a higher target …

Background The most appropriate targets for systolic blood pressure to reduce
cardiovascular morbidity and mortality among persons without diabetes remain uncertain …

Background: In individuals with a low diastolic blood pressure (DBP), the potential benefits
or risks of intensive systolic blood pressure (SBP) lowering are unclear. Methods: SPRINT …

Importance High blood pressure (BP) is a leading contributor to premature mortality
worldwide. The Systolic Blood Pressure Intervention Trial (SPRINT) demonstrated a 27 …

Background In the Systolic Blood Pressure Intervention Trial (SPRINT), adults at high risk for
cardiovascular disease who received intensive systolic blood-pressure control (target,< 120 …

Background Guidelines recommend intensive blood pressure (BP) lowering in patients at
high risk. While placebo-controlled trials have demonstrated 22% reductions in coronary …

Background Recent hypertension guidelines have reversed previous recommendations for
lower blood pressure targets in high-risk patients, such as those with cardiovascular …

Importance The appropriate treatment target for systolic blood pressure (SBP) in older
patients with hypertension remains uncertain. Objective To evaluate the effects of intensive …