Background: The depressive phase of bipolar disorder causes significant functional
impairment and disease burden. The efficacy and safety of antidepressants in the treatment …

Objective We investigated the comparative efficacy and tolerability of pharmacological
treatment strategies for the treatment of acute bipolar depression. Data sources A systematic …

Background Although mania and hypomania define bipolar disorder, depressive episodes
are more common and impairing, with few proven treatments. Adjunctive therapy with …

Objective: The role of antidepressants in the acute treatment of bipolar depression remains a
contentious issue. A previous meta-analysis of randomized controlled trials (RCTs) …

Objective: We investigated the comparative efficacy and tolerability of augmentation
strategies for bipolar depression. Data Sources: We conducted a systematic review and …

While studies in the past have focused more on treatment of the manic phase of bipolar
disorder (BD), recent findings demonstrate the depressive phase to be at least as …

This updated meta-analysis aims to evaluate the efficacy of adjunctive antidepressants in
the treatment of bipolar depression. The antidepressant group exhibited a significant …

Background Bipolar depression constitutes a major public health problem due to its
substantial burden of disease. Although pharmacological interventions are available …

The treatment of the depressed phase of Bipolar Disorder (BPD) is understudied and poses
a widespread clinical dilemma. While the use of mood stabilizers in BPD is a common …

Bipolar depression remains a major unresolved challenge for psychiatric therapeutics. It is
associated with significant disability and mortality and represents the major proportion of the …