Recent advances in molecular pathways and therapeutic implications targeting mitochondrial dysfunction for Alzheimer's disease
Alzheimer's disease (AD) is a neurodegenerative disorder which leads to mental
deterioration due to aberrant accretion of misfolded proteins in the brain. According to …
deterioration due to aberrant accretion of misfolded proteins in the brain. According to …
Mitochondrial dysfunction: a potential therapeutic target to treat Alzheimer's disease
Mitochondrial dysfunction plays a very vital role in the pathogenesis of Alzheimer's disease
(AD). Several shreds of evidence have indicated that the mitochondrial function is severely …
(AD). Several shreds of evidence have indicated that the mitochondrial function is severely …
Disentangling mitochondria in Alzheimer's disease
A Johri - International journal of molecular sciences, 2021 - mdpi.com
Alzheimer's disease (AD) is a major cause of dementia in older adults and is fast becoming
a major societal and economic burden due to an increase in life expectancy. Age seems to …
a major societal and economic burden due to an increase in life expectancy. Age seems to …
Mitochondrial dysfunction as a driver of cognitive impairment in Alzheimer's disease
Alzheimer's disease (AD) is the most frequent cause of age-related neurodegeneration and
cognitive impairment, and there are currently no broadly effective therapies. The underlying …
cognitive impairment, and there are currently no broadly effective therapies. The underlying …
A review on mitochondrial restorative mechanism of antioxidants in Alzheimer's disease and other neurological conditions
A Kumar, A Singh - Frontiers in pharmacology, 2015 - frontiersin.org
Neurodegenerative diseases are intricate in nature because of the involvement of the
multiple pathophysiological events including mitochondrial dysfunction, neuroinflammation …
multiple pathophysiological events including mitochondrial dysfunction, neuroinflammation …
Mitochondrial mechanisms in Alzheimer's disease: Quest for therapeutics
K Kalani, P Chaturvedi, P Chaturvedi, VK Verma… - Drug Discovery …, 2023 - Elsevier
Highlights•Mitochondria decide the progression of Alzheimer's disease.•AD pathology and
severity are determined by mitochondrial dynamics and energetic mechanisms.•Mitophagy …
severity are determined by mitochondrial dynamics and energetic mechanisms.•Mitophagy …
Key role of mitochondria in Alzheimer's disease synaptic dysfunction
V Cavallucci, C Ferraina… - Current pharmaceutical …, 2013 - ingentaconnect.com
Neuronal transmission and functional synapses require mitochondria, which are mainly
involved in the generation of energy (ATP and NAD+), regulation of cell signaling and …
involved in the generation of energy (ATP and NAD+), regulation of cell signaling and …
Mitochondria as potential targets in Alzheimer disease therapy: an update
G Cenini, W Voos - Frontiers in pharmacology, 2019 - frontiersin.org
Alzheimer disease (AD) is a progressive and deleterious neurodegenerative disorder that
affects mostly the elderly population. At the moment, no effective treatments are available in …
affects mostly the elderly population. At the moment, no effective treatments are available in …
Insights into the pathogenesis of neurodegenerative diseases: Focus on mitochondrial dysfunction and oxidative stress
A Jurcau - International journal of molecular sciences, 2021 - mdpi.com
As the population ages, the incidence of neurodegenerative diseases is increasing. Due to
intensive research, important steps in the elucidation of pathogenetic cascades have been …
intensive research, important steps in the elucidation of pathogenetic cascades have been …
The role of mitochondrial defects and oxidative stress in Alzheimer's disease
Alzheimer's disease (AD) is a complex, progressive, and irreversible neurodegenerative
disorder. Recent reports suggest that it affects more than 36 million people worldwide and …
disorder. Recent reports suggest that it affects more than 36 million people worldwide and …