Left–right asymmetry in the nervous system: the Caenorhabditis elegans model

O Hobert, RJ Johnston Jr, S Chang - Nature Reviews Neuroscience, 2002 - nature.com
Although the overall architecture of the nervous system of most animals shows a large
degree of bilateral symmetry, there are striking patterns of left–right (L–R) asymmetry in the …

Development of left/right asymmetry in the Caenorhabditis elegans nervous system: from zygote to postmitotic neuron

O Hobert - genesis, 2014 - Wiley Online Library
Despite their gross morphological symmetry, animal nervous systems can perceive and
process information in a left/right asymmetric manner. How left/right asymmetric functional …

[HTML][HTML] Early embryonic programming of neuronal left/right asymmetry in C. elegans

RJ Poole, O Hobert - Current Biology, 2006 - cell.com
Background Nervous systems are largely bilaterally symmetric on a morphological level but
often display striking degrees of functional left/right (L/R) asymmetry. How L/R asymmetric …

Making a difference together: reciprocal interactions in C. elegans and zebrafish asymmetric neural development

RW Taylor, YW Hsieh, JT Gamse… - Development, 2010 - journals.biologists.com
Brain asymmetries are thought to increase neural processing capacity and to prevent
interhemispheric conflict. In order to develop asymmetrically, neurons must be specified …

[HTML][HTML] Brain and behavioral lateralization in invertebrates

E Frasnelli - Frontiers in psychology, 2013 - frontiersin.org
Traditionally, only humans were thought to exhibit brain and behavioral asymmetries, but
several studies have revealed that most vertebrates are also lateralized. Recently, evidence …

Encoding asymmetry within neural circuits

ML Concha, IH Bianco, SW Wilson - Nature Reviews Neuroscience, 2012 - nature.com
Genetic and environmental factors control morphological and functional differences between
the two sides of the nervous system. Neural asymmetries are proposed to have important …

[HTML][HTML] Embryonic priming of a miRNA locus predetermines postmitotic neuronal left/right asymmetry in C. elegans

L Cochella, O Hobert - Cell, 2012 - cell.com
The mechanisms by which functional left/right asymmetry arises in morphologically
symmetric nervous systems are poorly understood. Here, we provide a mechanistic …

Cis-regulatory mechanisms of left/right asymmetric neuron-subtype specification in C. elegans

JF Etchberger, EB Flowers, RJ Poole, E Bashllari… - 2009 - journals.biologists.com
Anatomically and functionally defined neuron types are sometimes further classified into
individual subtypes based on unique functional or molecular properties. To better …

[HTML][HTML] Asymmetric activity of NetrinB controls laterality of the Drosophila brain

F Lapraz, C Boutres, C Fixary-Schuster… - Nature …, 2023 - nature.com
Left-Right (LR) asymmetry of the nervous system is widespread across animals and is
thought to be important for cognition and behaviour. But in contrast to visceral organ …

Timing and mechanism of the initial cue establishing handed left–right asymmetry in Caenorhabditis elegans embryos

S Schonegg, AA Hyman, WB Wood - Genesis, 2014 - Wiley Online Library
By the six‐cell stage, embryos of Caenorhabditis elegans are morphologically L–R
asymmetric with an invariant handedness that persists throughout development. We used …