Prostate cancer (PCa) is a disease that arises from cells in the prostate and in recent years it
has become increasingly evident that current treatment strategies for advanced PCa such …

Background: Neuroendocrine (NE) phenotype contributes to 25 to 30% androgen
deprivation resistant prostate cancer cases. Until now, this aggressive phenotype is …

Background The HOX genes are a family of transcription factors that help to determine cell
and tissue identity during early development, and which are also over-expressed in a …

HOX gene-encoded homeobox proteins control body patterning during embryonic
development; the specific expression pattern of HOX genes may correspond to tissue …

Purpose: The aberrant activity of developmental pathways in prostate cancer may provide
significant insight into predicting tumor initiation and progression, as well as identifying …

The recent and exciting discovery of germline HOXB13 mutations in familial prostate cancer
has brought HOX signaling to the forefront of prostate cancer research. An enhanced …

BACKGROUND Homeobox (HOX) genes, which are involved in organ development and
homeostasis, have been shown to be involved in normal prostate‐and PCa development. In …

Hox transcription factors play critical roles during development and reactivation may
participate in tumorigenesis. For example, some prostate cancers overexpress androgen …

Aberrant expression of HOXC6 and HOXC4 is commonly detected in prostate cancer. The
high expression of these transcription factors is associated with aggressive prostate cancer …

Background: HOX genes encode Homeobox-containing proteins. There are 39 HOX genes
organized into 4 clusters in human. The nested and partially overlapping expression of HOX …