Cannabis sativa, like all known drugs of abuse, leads to increased dopamine activation
within the mesolimbic pathway. Consequent dopamine release within terminal regions of the …

Increases in mesolimbic dopamine transmission are observed when animals are treated
with all known drugs of abuse, including cannabis, and to conditioned stimuli predicting their …

The last decades have seen a major gain in understanding the action of cannabinoids and
the endocannabinoid system in reward processing and the development of addictive …

Endogenous cannabinoids play important roles in a variety of functions in the mammalian
brain, including the regulation reward-related information processing. The primary …

Evidence suggests that the endocannabinoid system has been conserved in the animal
kingdom for 500 million years, and this system influences many critical behavioral processes …

Substantial evidence suggests that all commonly abused drugs act upon the brain reward
circuitry to ultimately increase extracellular concentrations of the neurotransmitter dopamine …

The mesolimbic dopamine (DA) system plays an integral role in incentive motivation and
reward seeking and a growing body of evidence identifies signal transduction at …

Drug dependence is a chronically relapsing disorder, manifested as an intense desire for
the drug, with impaired ability to control the urges to take the drug, even at the expense of …

Marijuana is the most popular illegal drug worldwide. Recent trends indicate that this may
soon change; not due to decreased marijuana use, but to an amendment in marijuana's …

With few exceptions, addicting drugs enhance electrical brain-stimulation reward and act as
direct or indirect dopamine agonists in the reward-relevant dopaminergic projections of the …