Chrysin, a PPAR-γ agonist improves myocardial injury in diabetic rats through inhibiting AGE-RAGE mediated oxidative stress and inflammation

N Rani, S Bharti, J Bhatia, TC Nag, R Ray… - Chemico-biological …, 2016 - Elsevier
AGE-RAGE interaction mediated oxidative stress and inflammation is the key mechanism
involved in the pathogenesis of cardiovascular disease in diabetes. Inhibition of AGE-RAGE …

Cinnamaldehyde ameliorates STZ-induced rat diabetes through modulation of IRS1/PI3K/AKT2 pathway and AGEs/RAGE interaction

ME Abdelmageed, GS Shehatou… - Naunyn-Schmiedeberg's …, 2019 - Springer
Type 2 diabetes mellitus (T2D) is a chronic metabolic disorder considered to be the most
predominant form of diabetes throughout the world. This study aimed to investigate the …

Mechanistic insights into the effects of quercetin and/or GLP-1 analogue liraglutide on high-fat diet/streptozotocin-induced type 2 diabetes in rats

HH Gaballah, SS Zakaria, SE Mwafy… - Biomedicine & …, 2017 - Elsevier
Background The development of complementary treatment strategies that focuses on
achieving a balance between adaptive and apoptotic unfolded protein response (UPR) …

[HTML][HTML] Syzygium jambos extract mitigates pancreatic oxidative stress, inflammation and apoptosis and modulates hepatic IRS-2/AKT/GLUT4 signaling pathway in …

MF Mahmoud, S Abdelaal, HO Mohammed… - Biomedicine & …, 2021 - Elsevier
The protective effect of Syzygium jambos (SJ) bark extract against streptozotocin-induced
diabetes was tested in rats. Animals were treated with 100 or 200 mg/kg of the extract or …

Chrysin attenuates high glucose-induced BMSC dysfunction via the activation of the PI3K/AKT/Nrf2 signaling pathway

Y Li, X Wang - Drug Design, Development and Therapy, 2022 - Taylor & Francis
Purpose High glucose environment in diabetes mellitus induces the dysfunction of bone
marrow-derived mesenchymal stromal cells (BMSCs) and impairs bone regeneration …

Ameliorative effects of glycyrrhizin on streptozotocin-induced diabetes in rats

S Sen, M Roy, AS Chakraborti - Journal of Pharmacy and …, 2011 - academic.oup.com
Objectives Glycyrrhizin is the main water-soluble constituent of the root of liquorice
(Glycyrrhiza glabra). The study investigates the effect of glycyrrhizin on streptozotocin (STZ) …

Crocetin suppresses gestational diabetes in streptozotocin‐induced diabetes mellitus rats via suppression of inflammatory reaction

Y Zheng, N Zhu, J Wang, N Zhao… - Journal of Food …, 2021 - Wiley Online Library
Gestational diabetes mellitus (GDM) is the serious complication of pregnancy induced via
dysfunction in glucose metabolism during the pregnancy. Crocetin already proved …

The Hypoglycemic and Renal Protection Properties of Crocin via Oxidative Stress-Regulated NF-κB Signaling in db/db Mice

Y Qiu, X Jiang, D Liu, Z Deng, W Hu, Z Li… - Frontiers in …, 2020 - frontiersin.org
Background As the main ingredient of Crocus sativus L.(Iridaceae) extract, crocin-I (CR) has
been reported to show various pharmacological activities. The aim of this study was to …

Garlic and resveratrol attenuate diabetic complications, loss of β-cells, pancreatic and hepatic oxidative stress in streptozotocin-induced diabetic rats

G Kaur, R Padiya, R Adela, UK Putcha… - Frontiers in …, 2016 - frontiersin.org
The study was aimed at finding the effect of garlic and resveratrol on loss of β-cells and
diabetic complication in streptozotocin (STZ)-induced Type-I diabetic rats. Rats were …

[HTML][HTML] Protective effects of syringin against oxidative stress and inflammation in diabetic pregnant rats via TLR4/MyD88/NF-κB signaling pathway

Z Shen, C Yang, P Zhu, C Tian, A Liang - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Gestational diabetes (GDM) is common in pregnancies due to the inflammation and
oxidative stress-mediated insulin resistance. In the present study, GDM was induced in the …