Aims Diabetes, a serious worldwide problem, is modulated via inflammation and oxidative
stress. Bromelain, a natural compound, recently attracts interest due to its anti-inflammatory …

Background: Diabetes mellitus (DM) is a metabolic disorder that occurs as a result of
absolute or relative insufficiency of insulin release and/or insulin effect due to impairment of …

RESULTS Hesperetin (0–100 μM, 48 h) treatment did not affect cell viability. The tumor
necrosis factor-α and interleukin-6 levels increased in cells co-treated with LPS under …

Background Oxidative stress has been implicated in the onset and progression of diabetes.
Tongxinluo is a traditional Chinese medicine with potent antioxidant properties. The aim of …

Background: Type 2 Diabetes Mellitus (T2DM) is a world-wide metabolic disease with no
cure from drugs and treatment. In China, The Traditional Chinese Medicine (TCM) herbal …

Protective effects of peroxiredoxin 6 (PRDX6) in RIN-m5F β-cells and of thymulin in mice
with alloxan-induced diabetes were recently reported. The present work was aimed at …

Type 1 diabetes (T1DM) is associated with increased vascular complications and is a pro-
inflammatory state. Recent findings have shown increased TLR2 and 4 expression …

Aim Currently, drugs for the treatment of diabetic nephropathy (DN) are lacking. This study
aimed to explore the protective effect of crocin on DN. Main methods Diabetes was induced …

Myocardial fibrosis is one of the major complications of long-term diabetes. Hyperglycemia
induced cardiomyocyte atrophy is a frequent pathophysiological indicator of diabetic heart …

Objective (s): Methylglyoxal (MG) provokes endoplasmic reticulum (ER) stress in β-cells and
triggers pancreatic β-cell dysfunction. Crocin has anti-diabetic properties. The present study …