Quercetin improves glucose and lipid metabolism of diabetic rats: involvement of Akt signaling and SIRT1

J Peng, Q Li, K Li, L Zhu, X Lin, X Lin… - Journal of diabetes …, 2017 - Wiley Online Library
Glucose and lipid metabolism disorder in diabetes mellitus often causes damage to multiple
tissues and organs. Diabetes mellitus is beneficially affected by quercetin. However, its …

[HTML][HTML] Anti-diabetic effects and mechanisms of action of a Chinese herbal medicine preparation JQ-R in vitro and in diabetic KKAy mice

Q Liu, S Liu, L Gao, S Sun, Y Huan, C Li… - … pharmaceutica sinica B, 2017 - Elsevier
Abstract Refined-JQ (JQ-R) is a mixture of refined extracts from Coptis chinensis
(Ranunculaceae), Astragalus membranaceus (Leguminosae) and Lonicera japonica …

Biochemical study on the protective effect of ethanolic extract of Zygophyllum album on streptozotocin-induced oxidative stress and toxicity in mice

J El Ghoul, N Ghanem-Boughanmi… - Biomedicine & Preventive …, 2011 - Elsevier
This study aims at the assessment of the effect of Zygophyllum album extract on β-cell
damage and antioxidant defence systems of liver and pancreas against the streptozotocin …

Black seed thymoquinone improved insulin secretion, hepatic glycogen storage, and oxidative stress in streptozotocin‐induced diabetic male wistar rats

HMA Abdelrazek, OE Kilany… - Oxidative medicine …, 2018 - Wiley Online Library
Diabetes mellitus is one of the metabolic diseases having several complications. Nigella
sativa oil (NSO) might have beneficial effects in the treatment of diabetic complications …

Carpachromene ameliorates insulin resistance in HepG2 cells via modulating IR/IRS1/PI3k/Akt/GSK3/FoxO1 pathway

R Alaaeldin, IAM Abdel-Rahman, HA Hassan… - Molecules, 2021 - mdpi.com
Insulin resistance contributes to several disorders including type 2 diabetes and
cardiovascular diseases. Carpachromene is a natural active compound that inhibits α …

A novel gastroprotective effect of zeaxanthin against stress-induced gastritis in male rats targeting the expression of HIF-1α, TFF-1 and MMP-9 through PI3K/Akt/JNK …

MG Elhadidy, EM El Nashar, MA Alghamdi, SM Samir - Life Sciences, 2021 - Elsevier
Stress-induced gastritis is a common problem in the intensive care unit. Zeaxanthin (ZE), a
non-provitamin A carotenoid has been known to exert antioxidant and anti-inflammatory …

Zerumbone, a tropical ginger sesquiterpene, ameliorates streptozotocin-induced diabetic nephropathy in rats by reducing the hyperglycemia-induced inflammatory …

TF Tzeng, SS Liou, CJ Chang, IM Liu - Nutrition & metabolism, 2013 - Springer
Background Zerumbone is one of the pungent constituents of Zingiber zerumbet (L) Smith
(Zingiberaceae family). The aim of the present study was to examine the effects of …

Protective effect of quercetin on hyperglycemia, oxidative stress and DNA damage in alloxan induced type 2 diabetic mice

MM Alam, D Meerza, I Naseem - Life sciences, 2014 - Elsevier
Aims Quercetin is a natural polyphenolic flavonoid and acts as a quencher for reactive
oxygen species generated by any physical or chemical action. In type 2 diabetes mellitus …

Silychristin A activates Nrf2-HO-1/SOD2 pathway to reduce apoptosis and improve GLP-1 production through upregulation of estrogen receptor α in GLUTag cells

J Wang, X Zhang, L Zhang, T Yan, B Wu, F Xu… - European Journal of …, 2020 - Elsevier
Abstract Glucagon-like peptide-1 (GLP-1), a glucagon-like peptide secreted mainly from
intestinal L cells, possesses the functions of promoting synthesis and secretion of insulin in …

[HTML][HTML] The protective role of shenqi compound in type 2 diabetes: a comprehensive investigation of pancreatic β-cell function and mass

C Yang, H Liu, Z Xie, Q Yang, L Du, C Xie - Biomedicine & …, 2023 - Elsevier
Abstract Type 2 diabetes (T2D) is a prevalent metabolic disorder characterized by impaired
insulin secretion and insulin resistance, resulting in elevated blood glucose levels. The …