Statistical Optimizing of Medium for Clavulanic Acid Production by Streptomyces clavuligerus Using Response Surface Methodology

T Feng, J Zhao, J Chu, Y Wang, Y Zhuang - Applied Biochemistry and …, 2021 - Springer
Clavulanic acid (CA) is a naturally occurring antibiotic produced by Streptomyces
clavuligerus. Statistical optimization of the fermentation medium for CA production by …

Optimization of medium composition for the production of clavulanic acid by Streptomyces clavuligerus

YH Wang, B Yang, J Ren, ML Dong, D Liang, AL Xu - Process Biochemistry, 2005 - Elsevier
The optimization of medium components for the production of clavulanic acid by
Streptomyces clavuligerus was performed using both factional factorial design and response …

A statistical approach using L25 orthogonal array method to study fermentative production of clavulanic acid by Streptomyces clavuligerus MTCC 1142

PS Saudagar, RS Singhal - Applied biochemistry and biotechnology, 2007 - Springer
Clavulanic acid is a naturally occurring antibiotic produced by Streptomyces clavuligerus.
The present work reports on clavulanic acid production by Streptomyces clavuligerus MTCC …

Optimization of nutritional requirements and feeding strategies for clavulanic acid production by Streptomyces clavuligerus

PS Saudagar, RS Singhal - Bioresource Technology, 2007 - Elsevier
The present work reports the nutritional requirements and environmental conditions for
submerged culture of Streptomyces clavuligerus for clavulanic acid production using …

[HTML][HTML] Streptomyces clavuligerus strain selection for clavulanic acid biosynthesis: A study based on culture composition effects and statistical analysis

L Pinilla, LF Toro, C Avignone-Rossa, M Peñuela… - Dyna, 2018 - scielo.org.co
The clinical and industrial importance of clavulanic acid (CA) promotes the search for novel
strategies to boost productivity at lower costs. In this contribution, the production of CA was …

Optimization of solid state medium for the production of clavulanic acid by Streptomyces clavuligerus

A Sircar, P Sridhar, PK Das - Process Biochemistry, 1998 - Elsevier
The composition of solid medium employed in solid state fermentation to obtain clavulanic
acid in batch cultures of Streptomyces clavuligerus by factorial design has been studied …

[HTML][HTML] A study on clavulanic acid production by Streptomyces clavuligerus in batch, fed-batch and continuous processes

AB Neto, DB Hirata, LCM Cassiano Filho… - Brazilian Journal of …, 2005 - SciELO Brasil
Clavulanic acid (CA) is a potent inhibitor of beta-lactamases, enzymes that are responsible
for the hydrolysis of beta-lactam antibiotics. It is a secondary metabolite produced by the …

[HTML][HTML] Optimization of clavulanic acid production by Streptomyces daufpe 3060 by response surface methodology

DAV Marques, MNC Cunha, JM Araújo… - Brazilian Journal of …, 2011 - SciELO Brasil
Clavulanic acid is a β-lactam antibiotic which has a potent β-lactamase inhibiting activity. In
order to optimize its production by the new isolate Streptomyces DAUFPE 3060, the …

Rational selection of culture medium for clavulanic acid production by Streptomyces clavuligerus based on a metabolic modeling approach

D Gómez-Riosa, H Ramírez-Malule… - Agriculture and …, 2022 - li01.tci-thaijo.org
Importance of the work: Clavulanic acid (CA) is a β-lactam antibiotic produced by
Streptomyces clavuligerus and is an inhibitor of β-lactamase enzymes responsible for …

Optimisation of medium composition for clavulanic acid production by Streptomyces clavuligerus

ER Gouveia, A Baptista-Neto, AC Badino Jr… - Biotechnology …, 2001 - Springer
Among four different commercially available nitrogen sources containing soybean
derivatives, a protein extract of soybean gave the highest yield for clavulanic acid production …