Fluorogenic probes that signal the presence of specific DNA or RNA sequences are key
enabling tools for molecular disease diagnosis and imaging studies. Usually, at least one …

Fluorescently labeled oligonucleotides are commonly employed as probes to detect specific
DNA or RNA sequences in homogeneous solution. Useful probes should experience strong …

Fluorescent base analogues in DNA are versatile probes of nucleic acid–nucleic acid and
nucleic acid–protein interactions. New peptide nucleic acid (PNA) based probes are …

Conspectus The increasing importance assigned to RNA dynamics in cells and tissues calls
for probe molecules that enable fluorescence microscopy imaging in live cells. To achieve …

We report on a new method for the detection of a base at a specific site in a DNA sequence
by monitoring the fluorescence emission of fluorescein. To achieve this goal, we developed …

Fluorescence detection and imaging are vital technologies in the life sciences and clinical
diagnostics. The key to obtaining high-resolution images and sensitive detection is to use …

An orange‐and a red‐emitting tetrazine‐modified cyanine‐styryl dyes were synthesized for
bioorthogonal labelling of DNA by means of the Diels‐Alder reaction with inverse electron …

DNA-directed chemical ligations provide the opportunity to diagnose DNA sequences with
very high sequence specificity. Fluorescent labels have been attached to reactive probes to …

Asymmetrically localized RNA has been found in many cell types and organisms and
contributes to important developmental processes, such as mating type switching in yeast,[1] …

The unfathomable role that fluorescence detection plays in the life sciences has prompted
the development of countless fluorescent labels, sensors, and analytical techniques that can …