To facilitate the preparation of synthetic epitope-based self-adjuvanting vaccines capable of
eliciting antibody responses in an out-bred population, we have developed two modular …

Synthetic lipopeptide vaccines are being increasingly investigated mainly because of the
advantages they offer over traditional vaccines, including safety of use in humans, high …

The technology described here allows the chemical synthesis of vaccines requiring correctly
folded epitopes and that contain difficult or long peptide sequences. The final self …

Adjuvant development and understanding the physicochemical properties of particles and
interpreting the subsequent immunological responses is a challenge faced by many …

Synthetic analogues of triacylated and diacylated lipopeptides derived from the N-terminal
domain of respectively bacterial and mycoplasmal lipoproteins are highly potent …

Synthetic immunogens, containing builtin adjuvanticity, B cell, T helper cell and CTL
epitopes or mimotopes, are ideal and invaluable tools to study the immune response with …

Peptide-based vaccines offer several advantages over conventional whole organism or
protein approaches by offering improved purity and specificity in inducing immune response …

Summary Effective Th1-and Th2-type immune responses that result in protective immunity
against pathogens can be induced by self-adjuvanting lipopeptides containing the lipid …

Despite the important role of adjuvants for vaccine development, relatively few adjuvants
have been successfully incorporated into vaccines intended for human administration. This …

Abstract The lipopeptide R 4 Pam 2 Cys is an agonist for toll-like receptor-2 (TLR2), a key
pathogen-associated molecular pattern receptor expressed on many antigen-presenting …