Genome wide association study and next generation sequencing: a glimmer of light toward new possible horizons in frontotemporal dementia research
M Ciani, L Benussi, C Bonvicini… - Frontiers in Neuroscience, 2019 - frontiersin.org
Frontotemporal Dementia (FTD) is a focal neurodegenerative disease, with a strong genetic
background, that causes early onset dementia. The present knowledge about the risk loci …
background, that causes early onset dementia. The present knowledge about the risk loci …
The missing heritability of sporadic frontotemporal dementia: new insights from rare variants in neurodegenerative candidate genes
M Ciani, C Bonvicini, C Scassellati, M Carrara… - International Journal of …, 2019 - mdpi.com
Frontotemporal dementia (FTD) is a common form of dementia among early-onset cases.
Several genetic factors for FTD have been revealed, but a large proportion of FTD cases still …
Several genetic factors for FTD have been revealed, but a large proportion of FTD cases still …
Frontotemporal dementia spectrum: first genetic screen in a Greek cohort
Frontotemporal dementia (FTD) is a heterogeneous group of neurodegenerative syndromes
associated with several causative and susceptibility genes. Herein, we aimed to determine …
associated with several causative and susceptibility genes. Herein, we aimed to determine …
[HTML][HTML] A genome-wide screening and SNPs-to-genes approach to identify novel genetic risk factors associated with frontotemporal dementia
Frontotemporal dementia (FTD) is the second most prevalent form of early onset dementia
after Alzheimer's disease (AD). We performed a case-control association study in an Italian …
after Alzheimer's disease (AD). We performed a case-control association study in an Italian …
Frontotemporal dementia and its subtypes: a genome-wide association study
Background Frontotemporal dementia (FTD) is a complex disorder characterised by a broad
range of clinical manifestations, differential pathological signatures, and genetic variability …
range of clinical manifestations, differential pathological signatures, and genetic variability …
The frontotemporal dementia prevention initiative: linking together genetic frontotemporal dementia cohort studies
Around one-third of frontotemporal dementia (FTD) is autosomal dominant with the major
genetic causes being mutations in MAPT, GRN and C9orf72. Studying familial forms of FTD …
genetic causes being mutations in MAPT, GRN and C9orf72. Studying familial forms of FTD …
The wide genetic landscape of clinical frontotemporal dementia: systematic combined sequencing of 121 consecutive subjects
C Blauwendraat, C Wilke, J Simón-Sánchez… - Genetics in …, 2018 - nature.com
Methods We investigated the frequencies and mutations in neurodegenerative disease
genes in 121 consecutive FTD subjects using an unbiased, combined sequencing …
genes in 121 consecutive FTD subjects using an unbiased, combined sequencing …
Clinico-genetic findings in 509 frontotemporal dementia patients
M Wagner, G Lorenz, AE Volk, T Brunet… - Molecular …, 2021 - nature.com
Frontotemporal dementia (FTD) is a clinically and genetically heterogeneous disorder. To
which extent genetic aberrations dictate clinical presentation remains elusive. We …
which extent genetic aberrations dictate clinical presentation remains elusive. We …
Genome-wide association study of frontotemporal dementia identifies a C9ORF72 haplotype with a median of 12-G4C2 repeats that predisposes to pathological …
Genetic factors play a major role in frontotemporal dementia (FTD). The majority of FTD
cannot be genetically explained yet and it is likely that there are still FTD risk loci to be …
cannot be genetically explained yet and it is likely that there are still FTD risk loci to be …
Frequency of frontotemporal dementia gene variants in C9ORF72, MAPT, and GRN in academic versus commercial laboratory cohorts
NZR Steele, AR Bright, SE Lee, JC Fong… - … in genomics and …, 2018 - Taylor & Francis
Background: Frontotemporal lobar degeneration (FTLD) is a leading cause of dementia, and
elucidating its genetic underpinnings is critical. FTLD research centers typically recruit …
elucidating its genetic underpinnings is critical. FTLD research centers typically recruit …