Genome wide association study and next generation sequencing: a glimmer of light toward new possible horizons in frontotemporal dementia research

M Ciani, L Benussi, C Bonvicini… - Frontiers in Neuroscience, 2019 - frontiersin.org
Frontotemporal Dementia (FTD) is a focal neurodegenerative disease, with a strong genetic
background, that causes early onset dementia. The present knowledge about the risk loci …

The missing heritability of sporadic frontotemporal dementia: new insights from rare variants in neurodegenerative candidate genes

M Ciani, C Bonvicini, C Scassellati, M Carrara… - International Journal of …, 2019 - mdpi.com
Frontotemporal dementia (FTD) is a common form of dementia among early-onset cases.
Several genetic factors for FTD have been revealed, but a large proportion of FTD cases still …

Frontotemporal dementia spectrum: first genetic screen in a Greek cohort

EM Ramos, C Koros, DR Dokuru, V Van Berlo… - Neurobiology of …, 2019 - Elsevier
Frontotemporal dementia (FTD) is a heterogeneous group of neurodegenerative syndromes
associated with several causative and susceptibility genes. Herein, we aimed to determine …

[HTML][HTML] A genome-wide screening and SNPs-to-genes approach to identify novel genetic risk factors associated with frontotemporal dementia

R Ferrari, M Grassi, E Salvi, B Borroni, F Palluzzi… - Neurobiology of …, 2015 - Elsevier
Frontotemporal dementia (FTD) is the second most prevalent form of early onset dementia
after Alzheimer's disease (AD). We performed a case-control association study in an Italian …

Frontotemporal dementia and its subtypes: a genome-wide association study

R Ferrari, DG Hernandez, MA Nalls, JD Rohrer… - The Lancet …, 2014 - thelancet.com
Background Frontotemporal dementia (FTD) is a complex disorder characterised by a broad
range of clinical manifestations, differential pathological signatures, and genetic variability …

The frontotemporal dementia prevention initiative: linking together genetic frontotemporal dementia cohort studies

JD Rohrer, AL Boxer - … Dementias: Emerging Milestones of the 21st …, 2021 - Springer
Around one-third of frontotemporal dementia (FTD) is autosomal dominant with the major
genetic causes being mutations in MAPT, GRN and C9orf72. Studying familial forms of FTD …

The wide genetic landscape of clinical frontotemporal dementia: systematic combined sequencing of 121 consecutive subjects

C Blauwendraat, C Wilke, J Simón-Sánchez… - Genetics in …, 2018 - nature.com
Methods We investigated the frequencies and mutations in neurodegenerative disease
genes in 121 consecutive FTD subjects using an unbiased, combined sequencing …

Clinico-genetic findings in 509 frontotemporal dementia patients

M Wagner, G Lorenz, AE Volk, T Brunet… - Molecular …, 2021 - nature.com
Frontotemporal dementia (FTD) is a clinically and genetically heterogeneous disorder. To
which extent genetic aberrations dictate clinical presentation remains elusive. We …

Genome-wide association study of frontotemporal dementia identifies a C9ORF72 haplotype with a median of 12-G4C2 repeats that predisposes to pathological …

LM Reus, IE Jansen, MO Mol, F van Ruissen… - Translational …, 2021 - nature.com
Genetic factors play a major role in frontotemporal dementia (FTD). The majority of FTD
cannot be genetically explained yet and it is likely that there are still FTD risk loci to be …

Frequency of frontotemporal dementia gene variants in C9ORF72, MAPT, and GRN in academic versus commercial laboratory cohorts

NZR Steele, AR Bright, SE Lee, JC Fong… - … in genomics and …, 2018 - Taylor & Francis
Background: Frontotemporal lobar degeneration (FTLD) is a leading cause of dementia, and
elucidating its genetic underpinnings is critical. FTLD research centers typically recruit …