The chronic cortical pathology of multiple sclerosis (MS) composes of demyelination and
neurodegeneration and has been studied since the early pathoanatomical descriptions of …

Modeling chronic cortical demyelination allows the study of long-lasting pathological
changes observed in multiple sclerosis such as failure of remyelination, chronically …

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central
nervous system (CNS). Recent studies suggest that, beside focal lesions, diffuse …

A substantial proportion of cases with secondary progressive multiple sclerosis have
extensive inflammation in the leptomeninges that is associated with increased subpial …

Multiple sclerosis is a chronic inflammatory disease of the CNS. Although progressive
axonal injury and diffuse inflammatory damage has been shown in the chronic phase of the …

Recent studies have revealed widespread demyelination in the cortex of patients with
chronic multiple sclerosis. In contrast to white matter lesions, cortical multiple sclerosis …

Although historically considered a disease primarily affecting the white matter of the central
nervous system, recent pathological and imaging studies have established that cortical …

Background Recent studies of cortical pathology in secondary progressive multiple sclerosis
have shown that a more severe clinical course and the presence of extended subpial grey …

The primary progressive form of multiple sclerosis is characterized by accrual of
neurological dysfunction from disease onset without remission and it is still a matter of …

Multiple sclerosis (MS) is an inflammatory and demyelinating disease of unknown aetiology
that causes neurological disabilities in young adults. MS displays different clinical patterns …