Delivery of CRISPR/Cas9 by novel strategies for gene therapy

L Wang, W Zheng, S Liu, B Li, X Jiang - ChemBioChem, 2019 - Wiley Online Library
Precise editing of the genome of a living body is a goal pursued by scientists in many fields.
In recent years, CRISPR (clustered regularly interspaced short palindromic repeat)/Cas …

[HTML][HTML] In vivo delivery of CRISPR-Cas9 therapeutics: Progress and challenges

M Behr, J Zhou, B Xu, H Zhang - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Within less than a decade since its inception, CRISPR-Cas9-based genome editing has
been rapidly advanced to human clinical trials in multiple disease areas. Although it is highly …

Delivery strategies of the CRISPR-Cas9 gene-editing system for therapeutic applications

C Liu, L Zhang, H Liu, K Cheng - Journal of controlled release, 2017 - Elsevier
The CRISPR-Cas9 genome-editing system is a part of the adaptive immune system in
archaea and bacteria to defend against invasive nucleic acids from phages and plasmids …

In vivo delivery of CRISPR/Cas9 for therapeutic gene editing: progress and challenges

R Mout, M Ray, YW Lee, F Scaletti… - Bioconjugate …, 2017 - ACS Publications
The successful use of clustered regularly interspaced short palindromic repeat
(CRISPR)/Cas9-based gene editing for therapeutics requires efficient in vivo delivery of the …

[HTML][HTML] CRISPR/Cas9 therapeutics: progress and prospects

T Li, Y Yang, H Qi, W Cui, L Zhang, X Fu, X He… - … and Targeted Therapy, 2023 - nature.com
Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated
protein 9 (Cas9) gene-editing technology is the ideal tool of the future for treating diseases …

[HTML][HTML] CRISPR/Cas9 delivery system engineering for genome editing in therapeutic applications

H Cheng, F Zhang, Y Ding - Pharmaceutics, 2021 - mdpi.com
The clustered regularly interspaced short palindromic repeats (CRISPR)/associated protein
9 (CRISPR/Cas9) systems have emerged as a robust and versatile genome editing platform …

[HTML][HTML] CRISPR/Cas9 systems: delivery technologies and biomedical applications

Y Du, Y Liu, J Hu, X Peng, Z Liu - Asian Journal of Pharmaceutical Sciences, 2023 - Elsevier
The emergence of the clustered regularly interspaced short palindromic repeats
(CRISPR)/CRISPR-associated protein 9 (Cas9) genome-editing system has brought about a …

CRISPR-Cas9 gene editing: Delivery aspects and therapeutic potential

EO Blenke, MJW Evers, E Mastrobattista… - Journal of Controlled …, 2016 - Elsevier
The CRISPR-Cas9 gene editing system has taken the biomedical science field by storm,
initiating rumors about future Nobel Prizes and heating up a fierce patent war, but also …

Delivery of CRISPR/Cas9 for therapeutic genome editing

X Xu, T Wan, H Xin, D Li, H Pan, J Wu… - The journal of gene …, 2019 - Wiley Online Library
The clustered, regularly‐interspaced, short palindromic repeat (CRISPR)‐associated
nuclease 9 (CRISPR/Cas9) is emerging as a promising genome‐editing tool for treating …

Development of delivery strategies for CRISPR‐Cas9 genome editing

Q Liu, J Yang, Y Xing, Y Zhao, Y Liu - BMEMat, 2023 - Wiley Online Library
The clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR‐
related protein 9 (Cas9) genome editing system has attracted much attention due to its …