Ketamine is a lipophilic, general anesthetic. When given at subanesthetic doses, it also has
been found to be an effective analgesic, with efficacy in cancer-associated neuropathic pain …

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Ketamine was originally developed as a potent but safe intravenous anesthetic drug which
has subsequently been used for premedication, sedation, induction, and maintenance of …

Ketamine has been in clinical use for over half a century, yet its precise mechanisms of
action remain mysterious for the large part. Its hypnotic effects appear to be largely mediated …

Ketamine is an intravenous drug with special properties that make it the only agent that
presently serves as anesthetic, sedative, amnesiac and analgesic. Although it is sometimes …

Highlights•Ketamine is an established dissociative anesthetic.•Ketamine's primary action
involves inhibition of N-methyl-D-aspartate (NMDA) receptors.•Ketamine also modulates …

The anaesthetic ketamine is used to treat various chronic pain syndromes, especially those
that have a neuropathic component. Low dose ketamine produces strong analgesia in …

Ketamine (2-(2-chlorophenyl)-2-(methylamino) cyclohexanone) is a phenylcyclidine
derivative originally developed in the 1960's as a medication to initiate and maintain …

Ketamine, a versatile anesthetic agent with a complex pharmacological profile, has been
utilized in clinical practice for decades3. This review examines the diverse mechanisms of …

Objectives: Describe the mode of action of ketamine. Identify the indications for ketamine
use in the management of pain. Summarize the complications of ketamine use and potential …