Chronic demyelination and axonal degeneration in multiple sclerosis: pathogenesis and therapeutic implications

TJ Simkins, GJ Duncan, D Bourdette - Current neurology and …, 2021 - Springer
Abstract Purpose of Review Multiple sclerosis (MS) is the most common demyelinating
disease of the central nervous system (CNS). Inflammatory attacks in MS lead to both …

Inflammation, demyelination, neurodegeneration and neuroprotection in the pathogenesis of multiple sclerosis

LK Peterson, RS Fujinami - Journal of neuroimmunology, 2007 - Elsevier
Although axonal loss has been observed in demyelinated multiple sclerosis (MS) lesions,
there has been a major focus on understanding mechanisms of demyelination. However …

Neurodegeneration in multiple sclerosis

GM Mey, KR Mahajan… - WIREs mechanisms of …, 2023 - Wiley Online Library
Axonal loss in multiple sclerosis (MS) is a key component of disease progression and
permanent neurologic disability. MS is a heterogeneous demyelinating and …

Neuroprotection and repair in multiple sclerosis

RJM Franklin, C Ffrench-Constant, JM Edgar… - Nature Reviews …, 2012 - nature.com
Multiple sclerosis (MS) is an inflammatory demyelinating disease that is considered by many
people to have an autoimmune aetiology. In recent years, new data emerging from …

Role of oligodendrocyte dysfunction in demyelination, remyelination and neurodegeneration in multiple sclerosis

AO Dulamea - Multiple Sclerosis: Bench to Bedside: Global …, 2017 - Springer
Oligodendrocytes (OLs) are the myelinating cells of the central nervous system (CNS) during
development and throughout adulthood. They result from a complex and well controlled …

The pathology of multiple sclerosis

CF Lucchinetti, J Parisi, W Bruck - Neurologic clinics, 2005 - neurologic.theclinics.com
Multiple sclerosis (MS) is a chronic neurologic disease affecting approximately 1 million
adults worldwide and 300,000 Americans [1]. Early illustrations by Carswell in 1838 and …

Mechanisms of neuronal dysfunction and degeneration in multiple sclerosis

R Dutta, BD Trapp - Progress in neurobiology, 2011 - Elsevier
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central
nervous system. Due to its high prevalence, MS is the leading cause of non-traumatic …

Axonal loss in multiple sclerosis: causes and mechanisms

G Criste, B Trapp, R Dutta - Handbook of clinical neurology, 2014 - Elsevier
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central
nervous system and the leading cause of non-traumatic neurologic disability in young adults …

Inflammation and degeneration in multiple sclerosis

W Brück, C Stadelmann - Neurological Sciences, 2003 - Springer
Multiple (MS) sclerosis is a chronic inflammatory demyelinating disease of the central
nervous system with the pathological hallmarks of inflammation, demyelination, axon loss …

[HTML][HTML] Diverse targets for intervention during inflammatory and neurodegenerative phases of multiple sclerosis

SS Zamvil, L Steinman - Neuron, 2003 - cell.com
Multiple sclerosis (MS) is an autoimmune central nervous system (CNS) demyelinating
disease that causes relapsing and chronic neurologic impairment. Recent observations …