Many new therapies have become available for multiple sclerosis patients during the last
decade. They are mainly effective in the early relapsing stage of the disease. Despite this …

Oligodendrocytes synthesize and maintain myelin in the central nervous system (CNS).
Damage may occur to these cells in a number of conditions, including infections, exposure …

Despite the large number of immunomodulatory or immunosuppressive treatments available
to treat relapsing–remitting multiple sclerosis (MS), treatment of the progressive phase of the …

There are two components to the treatment of multiple sclerosis (MS); the first is to prevent
damage occurring, and the second is to repair the residual damage. While considerable …

Neurodegeneration in multiple sclerosis (MS) is related to inflammation and demyelination.
In acute MS lesions and experimental autoimmune encephalomyelitis focal immune attacks …

Oligodendrocyte precursors are abundant in multiple sclerosis lesions, but fail to
remyelinate. Oligodendrocyte growth and regeneration are probably compromised by the …

Understanding the mechanisms of axonal mitochondrial response to a disturbance in myelin
and determining if certain aspects of the axonal mitochondrial response to demyelinated …

The restoration of myelin sheaths on demyelinated axons remains a major obstacle in the
treatment of multiple sclerosis (MS). Currently approved therapies work by modulating the …

J. Neurochem.(2010) 114, 1243–1260. Abstract In multiple sclerosis, CNS demyelination is
often followed by spontaneous repair, mostly achieved by adult oligodendrocyte precursor …

Axonal injury has been proposed as the basis of permanent deficits in the inflammatory,
demyelinating disease, multiple sclerosis. However, reports on the degree of injury are …