Interactive associations of vascular risk and β-amyloid burden with cognitive decline in clinically normal elderly individuals: findings from the Harvard Aging Brain …
JS Rabin, AP Schultz, T Hedden, A Viswanathan… - JAMA …, 2018 - jamanetwork.com
Importance Identifying asymptomatic individuals at high risk of impending cognitive decline
because of Alzheimer disease is crucial for successful prevention of dementia. Vascular risk …
because of Alzheimer disease is crucial for successful prevention of dementia. Vascular risk …
Vascular risk and β‐amyloid are synergistically associated with cortical tau
Objective Neuropathological studies have demonstrated that cerebrovascular disease and
Alzheimer disease (AD) pathology frequently co‐occur in older adults. The extent to which …
Alzheimer disease (AD) pathology frequently co‐occur in older adults. The extent to which …
The aging brain and cognition: contribution of vascular injury and aβ to mild cognitive dysfunction
NL Marchant, BR Reed, N Sanossian… - JAMA …, 2013 - jamanetwork.com
Importance β-Amyloid (Aβ) deposition and vascular brain injury (VBI) frequently co-occur
and are both associated with cognitive decline in aging. Determining whether a direct …
and are both associated with cognitive decline in aging. Determining whether a direct …
Vascular burden and Alzheimer disease pathologic progression
RY Lo, WJ Jagust, M Weiner, P Aisen, M Weiner… - Neurology, 2012 - AAN Enterprises
Objective: To investigate the vascular contribution to longitudinal changes in Alzheimer
disease (AD) biomarkers. Methods: The Alzheimer's Disease Neuroimaging Initiative is a …
disease (AD) biomarkers. Methods: The Alzheimer's Disease Neuroimaging Initiative is a …
Age, vascular health, and Alzheimer disease biomarkers in an elderly sample
P Vemuri, TG Lesnick, SA Przybelski… - Annals of …, 2017 - Wiley Online Library
Objective To investigate the associations between age, vascular health, and Alzheimer
disease (AD) imaging biomarkers in an elderly sample. Methods We identified 430 …
disease (AD) imaging biomarkers in an elderly sample. Methods We identified 430 …
Risk factors for β-amyloid deposition in healthy aging: vascular and genetic effects
Importance Identifying risk factors for increased β-amyloid (Aβ) deposition is important for
targeting individuals most at risk for developing Alzheimer disease and informing clinical …
targeting individuals most at risk for developing Alzheimer disease and informing clinical …
Vascular and amyloid pathologies are independent predictors of cognitive decline in normal elderly
P Vemuri, TG Lesnick, SA Przybelski, DS Knopman… - Brain, 2015 - academic.oup.com
Our primary objective was to investigate a biomarker driven model for the interrelationships
between vascular disease pathology, amyloid pathology, and longitudinal cognitive decline …
between vascular disease pathology, amyloid pathology, and longitudinal cognitive decline …
Association between midlife vascular risk factors and estimated brain amyloid deposition
Importance Midlife vascular risk factors have been associated with late-life dementia.
Whether these risk factors directly contribute to brain amyloid deposition is less well …
Whether these risk factors directly contribute to brain amyloid deposition is less well …
Aggregate effects of vascular risk factors on cerebrovascular changes in autopsy-confirmed Alzheimer's disease
KJ Bangen, DA Nation, L Delano-Wood… - Alzheimer's & …, 2015 - Elsevier
We examined the relationships of antemortem vascular risk factors to postmortem
cerebrovascular and Alzheimer's disease (AD) pathologies. Eighty-four AD patients …
cerebrovascular and Alzheimer's disease (AD) pathologies. Eighty-four AD patients …
Associations of physical activity and β-amyloid with longitudinal cognition and neurodegeneration in clinically normal older adults
JS Rabin, H Klein, DR Kirn, AP Schultz… - JAMA …, 2019 - jamanetwork.com
Importance In the absence of disease-modifying therapies for Alzheimer disease, there is a
critical need to identify modifiable risk factors that may delay the progression of Alzheimer …
critical need to identify modifiable risk factors that may delay the progression of Alzheimer …
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