This review focuses on the effects that ischemia and hypoxia have on the cerebral cortex
and the cerebellum during different periods of life. The acute interruption or reduction of …

Although free radicals have been suggested to contribute to ischemic brain damage for
more than 10 years, it is not until quite recently that convincing evidence has been …

It is now becoming increasingly clear that free radicals contribute to brain damage in several
conditions, such as hyperoxia and trauma. It has been more difficult to prove that free radical …

The possible role of free radicals and oxidative stress in neurological disorders was not
recognized until recently and thus is relatively unknown to practicing as well as …

The previous article outlined the biochemical basis and evidence for the occurrence of
oxygen radical generation and lipid peroxidation during the acute phase of central nervous …

Production of oxygen free radicals is a natural consequence of aerobic metabolism and they
are constantly generated in vivo by chemical reactions and metabolic processes. Antioxidant …

Brain ischemia initiates a complex cascade of metabolic events, several of which involve the
generation of nitrogen and oxygen free radicals. These free radicals and related reactive …

This review addresses current understanding of oxygen radical mechanisms as they relate
to the brain during ischemia and reperfusion. The mechanism for radical production remains …

We investigated the pathogenic role of free radical formation in ischemic neuronal death
using radical scavenger, Superoxide dismutase. Cerebral ischemia was produced in the …

A large body of evidence has appeared over the last 6 years suggesting that nitric oxide
biosynthesis is a key factor in the pathophysiological response of the brain to hypoxia …