The MYCN oncoprotein drives the development of numerous neuroendocrine and pediatric
tumors. Here we show that MYCN interacts with the nuclear RNA exosome, a 3′-5 …

MYC is an oncogenic transcription factor that binds globally to active promoters and
promotes transcriptional elongation by RNA polymerase II (RNAPII),. Deregulated …

Eukaryotic cells have evolved quality control mechanisms to degrade aberrant mRNA
molecules and prevent the synthesis of defective proteins that could be deleterious for the …

A defining feature of embryonic stem cells (ESCs) is the ability to differentiate into all three
germ layers. Pluripotency is maintained in part by a unique transcription network that …

Oncoproteins of the MYC family are major drivers of human tumorigenesis. Since a large
body of evidence indicates that MYC proteins are transcription factors, studying their function …

The exosome is an RNA-decay complex that constantly monitors transcription and
contributes to post-transcriptional turnover of faulty mRNAs. Yet how nuclear RNA …

Amplification of the oncogenic transcription factor MYCN plays a major role in the
pathogenesis of several pediatric cancers, including neuroblastoma, medulloblastoma, and …

Accurate target recognition in transcript degradation is crucial for regulation of gene
expression. In the fission yeast Schizosaccharomyces pombe, a number of meiotic …

Oncoproteins of the MYC family drive the development of numerous human tumours. In
unperturbed cells, MYC proteins bind to nearly all active promoters and control transcription …

Cancer cells have a raised cellular metabolism, including increased protein biosynthesis.
Three new studies now show that the oncoprotein Myc, known to drive cell division, also …