Transcriptomic profile of GLCs of PCOS women highlights metabolic dysregulation as a plausible contributor to PCOS pathophysiology
K Patil, A Naigaonkar, I Hinduja, S Mukherjee - Reproductive Biology, 2023 - Elsevier
Polycystic ovary syndrome (PCOS) is a complex heterogeneous disorder with reproductive
and metabolic consequences whose aetiology is still elusive. To understand the cellular …
and metabolic consequences whose aetiology is still elusive. To understand the cellular …
[HTML][HTML] Effects of androgen excess-related metabolic disturbances on granulosa cell function and follicular development
B Liao, X Qi, C Yun, J Qiao, Y Pang - Frontiers in endocrinology, 2022 - frontiersin.org
Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disease in women
of reproductive age. Ovarian dysfunction including abnormal steroid hormone synthesis and …
of reproductive age. Ovarian dysfunction including abnormal steroid hormone synthesis and …
Integrated bioinformatics analysis elucidates granulosa cell whole-transcriptome landscape of PCOS in China
Q Li, Y Sang, Q Chen, B Ye, X Zhou, Y Zhu - Journal of Ovarian Research, 2023 - Springer
Background Polycystic ovary syndrome (PCOS) is a common reproductive, neuroendocrine,
and metabolic disorder in women of reproductive age that affects up to 5–10% of women of …
and metabolic disorder in women of reproductive age that affects up to 5–10% of women of …
[HTML][HTML] Multiomics analysis reveals molecular abnormalities in granulosa cells of women with polycystic ovary syndrome
R Zhao, Y Jiang, S Zhao, H Zhao - Frontiers in genetics, 2021 - frontiersin.org
Polycystic ovary syndrome (PCOS) is the most common complex endocrine and metabolic
disease in women of reproductive age. It is characterized by anovulatory infertility, hormone …
disease in women of reproductive age. It is characterized by anovulatory infertility, hormone …
Deconvolution at the single-cell level reveals ovarian cell-type-specific transcriptomic changes in PCOS
S Li, Y Li, Y Sun, G Feng, Z Yang, X Yan, X Gao… - Reproductive Biology …, 2024 - Springer
Background Polycystic ovary syndrome (PCOS) is one of the most common reproductive
endocrine disorders in females of childbearing age. Various types of ovarian cells work …
endocrine disorders in females of childbearing age. Various types of ovarian cells work …
Identification of potential biomarkers of polycystic ovary syndrome via integrated bioinformatics analysis
D Yang, N Li, A Ma, F Dai, Y Zheng, X Hu, Y Wang… - Reproductive …, 2021 - Springer
Polycystic ovary syndrome (PCOS) is a life-long reproductive, endocrine, and metabolic
disorder that affects up to 17% of women of reproductive age. However, the effect of …
disorder that affects up to 17% of women of reproductive age. However, the effect of …
Disturbed Follicular Microenvironment in Polycystic Ovary Syndrome: Relationship to Oocyte Quality and Infertility
M Dai, L Hong, T Yin, S Liu - Endocrinology, 2024 - academic.oup.com
Polycystic ovary syndrome (PCOS) is a common endocrine disorder associated with
infertility and poor reproductive outcomes. The follicular fluid (FF) microenvironment plays a …
infertility and poor reproductive outcomes. The follicular fluid (FF) microenvironment plays a …
[HTML][HTML] Molecular features of polycystic ovary syndrome revealed by transcriptome analysis of oocytes and cumulus cells
J Li, H Chen, M Gou, C Tian, H Wang… - Frontiers in cell and …, 2021 - frontiersin.org
Polycystic ovary syndrome (PCOS) is typically characterized by a polycystic ovarian
morphology, hyperandrogenism, ovulatory dysfunction, and infertility. Furthermore, PCOS …
morphology, hyperandrogenism, ovulatory dysfunction, and infertility. Furthermore, PCOS …
Essential Role of Granulosa Cell Glucose and Lipid Metabolism on Oocytes and the Potential Metabolic Imbalance in Polycystic Ovary Syndrome
CH Zhang, XY Liu, J Wang - International Journal of Molecular Sciences, 2023 - mdpi.com
Granulosa cells are crucial for the establishment and maintenance of bidirectional
communication among oocytes. Various intercellular material exchange modes, including …
communication among oocytes. Various intercellular material exchange modes, including …
Integrated lipid metabolomics and proteomics analysis reveal the pathogenesis of polycystic ovary syndrome
Y Qian, Y Tong, Y Zeng, J Huang, K Liu, Y Xie… - Journal of Translational …, 2024 - Springer
Background Polycystic ovary syndrome (PCOS) is an endocrinological and metabolic
disorder that can lead to female infertility. Lipid metabolomics and proteomics are the new …
disorder that can lead to female infertility. Lipid metabolomics and proteomics are the new …