Background Secondary prevention clinical trials for Alzheimer's disease (AD) target amyloid
accumulation in asymptomatic, amyloid-positive individuals, but it is unclear to what extent …

Objective: Previous research established that white matter hyperintensities (WMH), a
biomarker of small vessel cerebrovascular disease, are strong predictors of cognitive …

Objective To cross-sectionally relate multiple small vessel disease (SVD) neuroimaging
markers to cognition among older adults. Methods Vanderbilt Memory & Aging Project …

Background and Objectives The severity of white matter hyperintensities (WMH) at
presentation with stroke is associated with poststroke dementia and dependency. However …

It remains unclear to what extent cerebrovascular burden relates to amyloid beta (Aβ)
deposition, neurodegeneration, and cognitive dysfunction in mixed disease populations with …

MRI-derived features of presumed cerebral small vessel disease are frequently found in
Alzheimer's disease. Influences of such markers on disease-progression measures are …

Objective To determine whether vascular and neurodegenerative factors influence cognition
before clinically relevant Alzheimer disease pathology, we analyzed MRI measures and …

ABSTRACT Objective Small Vessel Disease (SVD) is known to be associated with higher
AD risk, but its relationship to amyloidosis in the progression of AD is unclear. In this cross …

Abstract Introduction Cognitive decline in Alzheimer's disease is associated with amyloid
beta (Aβ) accumulation, neurodegeneration, and cerebral small vessel disease, but the …

Background Longitudinal investigations are needed to improve understanding of the
contributions of cerebral small vessel disease to the clinical manifestation of Alzheimer's …