[PDF][PDF] Heterogeneity of the exhausted hbv-specific cd8 t cell population as defined by functional/phenotypic profiling
M Rossi - 2020 - repository.unipr.it
Chronic hepatitis B virus (HBV) infection represents a public health problem worldwide with
approximately 250 million people chronically infected at increased risk of developing liver …
approximately 250 million people chronically infected at increased risk of developing liver …
[PDF][PDF] Determinants of virus-specific CD8+ T-cell failure in chronic HBV infection
E Salimi Alizei - freidok.uni-freiburg.de
The hallmark of successful viral elimination in hepatitis B virus (HBV) infection is a strong
and sustained cytotoxic CD8+ T-cell response. Two major mechanisms may result in CD8+ …
and sustained cytotoxic CD8+ T-cell response. Two major mechanisms may result in CD8+ …
Phenotypic CD8 T cell profiling in chronic hepatitis B to predict HBV-specific CD8 T cell susceptibility to functional restoration in vitro
Objective Exhausted hepatitis B virus (HBV)-specific CD8 T cells in chronic HBV infection
are broadly heterogeneous. Characterisation of their functional impairment may allow to …
are broadly heterogeneous. Characterisation of their functional impairment may allow to …
[PDF][PDF] Phenotypic and functional differences of HBV core-specific versus HBV polymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load
MM Kiraithe, J Kemming, S Llewellyn-Lacey… - scholar.archive.org
Objective A hallmark of chronic HBV (cHBV) infection is the presence of impaired HBV-
specific CD8+ T cell responses. Functional T cell exhaustion induced by persistent antigen …
specific CD8+ T cell responses. Functional T cell exhaustion induced by persistent antigen …
Overcoming CD8+ T-cell exhaustion in viral hepatitis: lessons from the mouse model and clinical perspectives
D Wieland, M Hofmann, R Thimme - Digestive Diseases, 2017 - karger.com
About 500 million people all over the world are chronically infected with hepatitis B virus
(HBV) or hepatitis C virus (HCV) and are thus at high risk of developing liver fibrosis …
(HBV) or hepatitis C virus (HCV) and are thus at high risk of developing liver fibrosis …
Enforced cytotoxic signature of HBV pol455-specific CD8 T cells in chronic HBV infection
K Heim, S Sagar, M Hofmann… - Zeitschrift für …, 2022 - thieme-connect.com
T-cell exhaustion represents a distinct T-cell differentiation program associated with chronic
viral infections. Several studies have shown that exhausted CD8+ T cells are …
viral infections. Several studies have shown that exhausted CD8+ T cells are …
Hepatitis B virus-specific CD4 T cell responses differentiate functional cure from chronic surface antigen+ infection
RC Hoogeveen, S Dijkstra, LM Bartsch… - Journal of …, 2022 - Elsevier
Background & Aims With or without antiviral treatment, few individuals achieve sustained
functional cure of chronic hepatitis B virus (HBV) infection. A better definition of what …
functional cure of chronic hepatitis B virus (HBV) infection. A better definition of what …
[HTML][HTML] Hepatitis B virus-specific CD8+ T cells maintain functional exhaustion after antigen reexposure in an acute activation immune environment
Q Wang, W Pan, Y Liu, J Luo, D Zhu, Y Lu… - Frontiers in …, 2018 - frontiersin.org
Chronic hepatitis B virus (HBV) infection is characterized by the presence of functionally
exhausted HBV-specific CD8+ T cells. To characterize the possible residual effector ability of …
exhausted HBV-specific CD8+ T cells. To characterize the possible residual effector ability of …
[HTML][HTML] Hepatitis B surface antigen reduction is associated with hepatitis B core-specific CD8+ T cell quality
S Takahama, S Yoshio, Y Masuta, H Murakami… - Frontiers in …, 2023 - frontiersin.org
Despite treatment, hepatitis B surface antigen (HBsAg) persists in patients with chronic
hepatitis B (CHB), suggesting the likely presence of the virus in the body. CD8+ T cell …
hepatitis B (CHB), suggesting the likely presence of the virus in the body. CD8+ T cell …
FUNCTIONAL AND TRANSCRIPTIONAL RESTORATION OF EXHAUSTED VIRUS-SPECIFIC T LYMPHOCYTES FROM PATIENTS WITH CHRONIC HEPATITIS B
C CECCATELLI BERTI, I Montali, M Morselli… - … virological concepts in …, 2023 - air.unipr.it
Background and Aims: The current therapy for chronic hepatitis B (CHB) is mainly based on
direct acting antiviral drugs that efficiently suppress virus replication, but don't eradicate HBV …
direct acting antiviral drugs that efficiently suppress virus replication, but don't eradicate HBV …