For ethical, economical, and scientific reasons, animal experimentation, used to evaluate the
potential neurotoxicity of chemicals before their release in the market, needs to be replaced …

The difficulty in mimicking nervous system complexity and cell–cell interactions as well as
the lack of kinetics information has limited the use of in vitro neurotoxicity data. Here, we …

Amiodarone is an antiarrhythmic agent inducing adverse effects on the nervous system,
among others. We applied physiologically based pharmacokinetic (PBPK) modeling …

Cardiotoxicity of pharmaceutical drugs, industrial chemicals, and environmental toxicants
can be severe, even life threatening, which necessitates a thorough evaluation of the human …

This project aims to establish and characterize an in vitro model of the developing human
brain for the purpose of testing drugs and chemicals. To accurately assess risk, a model …

Background: Chemicals are not required to be tested systematically for their neurotoxic
potency, although they may contribute to the development of several neurological diseases …

Growing concern suggests that some chemicals exert (developmental) neurotoxicity (DNT
and NT) and are linked to the increase in incidence of autism, attention deficit and …

The currently accepted methods for neurotoxicity (NT) testing rely on animal studies.
However, high costs and low testing throughput hinder their application for large numbers of …

Drug-induced neurotoxicity is a leading cause of safety-related attrition for therapeutics in
clinical trials, often driven by poor predictivity of preclinical in vitro and in vivo models of …

The recent development of human cerebral organoids provides an invaluable in vitro model
of human brain development to assess the toxicity of natural or man‐made toxic substances …