The progressive decline of the anatomical architecture and loss of functional integrity of an
individual is aging. Accumulation of degenerative cellular and molecular changes in the …

T cell survival, differentiation after stimulation, and function are intrinsically linked to distinct
cellular metabolic states. The ability of T cells to readily transition between metabolic states …

It is now clear that access to specific metabolic programmes controls the survival and
function of various immune cell populations, including T cells. Efficient naïve and memory T …

It is well known that aging is associated with dysregulated metabolism. This is seen both in
terms of systemic metabolism, as well as at the cellular level with clear mitochondrial …

Aging results in remodeling of T cell immunity and is associated with poor clinical outcomes
in age-related diseases such as cancer. Among the hallmarks of aging, changes in host and …

Beginning with the sixth decade of life, the human immune system undergoes dramatic
aging-related changes, which continuously progress to a state of immunosenescence. The …

The aging immune system is unable to optimally respond to pathogens and generate long-
term immunological memory against encountered antigens. Amongst the immune …

T cells are required for an effective adaptive immune response. The principal function of T
cells is to promote efficient removal of foreign material by identifying and mounting a specific …

Although the phenotype of T-cell senescence has been extensively investigated, few studies
have analyzed the factors that promote the generation and maintenance of naïve and …

Advancing age is accompanied by significant remodelling of the immune system, termed
immune senescence, and increased systemic inflammation, termed inflammageing, both of …