Deterioration of the immune system with aging (" immunosenescence") is believed to
contribute to morbidity and mortality in man due to the greater incidence of infection, as well …

The immune system is a tightly regulated network which allows the development of defense
mechanisms against foreign antigens and tolerance toward self-antigens. Regulatory T cells …

T cell-mediated immune responses are compromised in aged individuals, leading to
increased morbidity and reduced response to vaccination. While cellular metabolism tightly …

Highlights•T cells are highly influenced by persistent infections independently of age.•Up-
regulation of Tim3, PD-1, KLRG-1 and CD57 in aged T cells.•TF as Tbet/Eomes control T …

Highlights•There is a general signal transduction alteration in immune cells with human
aging.•The most important changes occur at the proximal signaling of TCR.•Not only the …

Constant exposure to new and persisting antigens and the need to replace cellular attrition
with newly built cells lead to profound remodeling of the immune system after the age of 50 …

Immunosenescence is a state of dysregulated leukocyte function characterised by arrested
cell cycle, telomere shortening, expression of markers of cellular stress, and secretion of pro …

Acquired immune function shows recognizable changes over time with organismal aging.
These changes include T-cell dysfunction, which may underlie diminished resistance to …

Adaptive immune responses that occur in infection, cancer, and autoimmune as well as
allergic diseases involve the participation of T cells. T cells travel throughout the body …

Despite its dynamic organization and self-renewal capacity, with large numbers of its cellular
components continually turning over and being replaced, the immune system in older …