[HTML][HTML] Aging and T-cell-mediated immunity
B Chakravarti, GN Abraham - Mechanisms of ageing and development, 1999 - Elsevier
Changes in the T-lymphocyte compartment represent the most critical component of
immunological aging. Recent studies have demonstrated that the age-related decline in T …
immunological aging. Recent studies have demonstrated that the age-related decline in T …
Intrinsic and extrinsic contributors to defective CD8+ T cell responses with aging
M Jergović, MJ Smithey, J Nikolich-Žugich - Experimental Gerontology, 2018 - Elsevier
Aging has a profound effect on the immune system, and both innate and adaptive arms of
the immune system show functional decline with age. In response to infection with …
the immune system show functional decline with age. In response to infection with …
Metabolic regulation of immune cells in proinflammatory microenvironments and diseases during ageing
PH Li, R Zhang, LQ Cheng, JJ Liu, HZ Chen - Ageing Research Reviews, 2020 - Elsevier
The process of ageing includes molecular changes within cells and interactions between
cells, eventually resulting in age-related diseases. Although various cells (immune cells …
cells, eventually resulting in age-related diseases. Although various cells (immune cells …
Immune aging–A mechanism in autoimmune disease
Evidence is emerging that the process of immune aging is a mechanism leading to
autoimmunity. Over lifetime, the immune system adapts to profound changes in …
autoimmunity. Over lifetime, the immune system adapts to profound changes in …
Signaling pathways in aged T cells–a reflection of T cell differentiation, cell senescence and host environment
JJ Goronzy, G Li, M Yu, CM Weyand - Seminars in immunology, 2012 - Elsevier
With increasing age, the ability of the immune system to protect against new antigenic
challenges or to control chronic infections erodes. Decline in thymic function and cumulating …
challenges or to control chronic infections erodes. Decline in thymic function and cumulating …
[HTML][HTML] When aging reaches CD4+ T-cells: phenotypic and functional changes
MA Moro-García, R Alonso-Arias… - Frontiers in …, 2013 - frontiersin.org
Beyond midlife, the immune system shows aging features and its defensive capability
becomes impaired, by a process known as immunosenescence that involves many changes …
becomes impaired, by a process known as immunosenescence that involves many changes …
[HTML][HTML] The ups and downs of metabolism during the lifespan of a T cell
Understanding the various mechanisms that govern the development, activation,
differentiation, and functions of T cells is crucial as it could provide opportunities for …
differentiation, and functions of T cells is crucial as it could provide opportunities for …
[HTML][HTML] Age-related increase of mitochondrial content in human memory CD4+ T cells contributes to ROS-mediated increased expression of proinflammatory …
Y Chen, Y Ye, PL Krauß, P Löwe… - Frontiers in …, 2022 - frontiersin.org
Cellular metabolism modulates effector functions in human CD4+ T (Th) cells by providing
energy and building blocks. Conversely, cellular metabolic responses are modulated by …
energy and building blocks. Conversely, cellular metabolic responses are modulated by …
[HTML][HTML] Markers of T cell senescence in humans
Many countries are facing the aging of their population, and many more will face a similar
obstacle in the near future, which could be a burden to many healthcare systems. Increased …
obstacle in the near future, which could be a burden to many healthcare systems. Increased …
[HTML][HTML] Successful and maladaptive T cell aging
JJ Goronzy, CM Weyand - Immunity, 2017 - cell.com
Throughout life, the T cell system adapts to shifting resources and demands, resulting in a
fundamentally restructured immune system in older individuals. Here we review the cellular …
fundamentally restructured immune system in older individuals. Here we review the cellular …