The thymus is one of the cornerstones of an effective immune system. It produces new T-
cells for the naïve T-cell pool, thus refreshing the peripheral repertoire. As we age, the …

The aging immune system demonstrates a reduced capacity to mount a robust immune
response (immunosenescence), thereby increasing the susceptibility to various infectious …

The bone marrow (BM) provides a preferential survival environment for the long-term
maintenance of antigen-experienced adaptive immune cells. After the contact with antigens …

Cellular senescence occurs not only in cultured fibroblasts, but also in undifferentiated and
specialized cells from various tissues of all ages, in vitro and in vivo. Here, we review recent …

The development of age-associated diseases is related to the accumulation of senescent
cells in the body. These are old non-functional cells with impaired metabolism, which are …

Immunological studies of aging and of patients with chronic immune-mediated diseases
document overlap of immune phenotypes. Here, the term 'immune remodeling'refers to …

Aging is associated with an alteration of the immune response called immunosenescence. It
is now well accepted that all parts of the immune system, the adaptive as well as the innate …

During an immune response, T cell differentiation and function are tightly regulated to
ensure protection against pathogens and prevent the autoimmune attack versus self …

T cells are essential for defending hosts against microorganisms and malignancy as well as
for regulating the development of immune-mediated inflammatory diseases like …

A fundamental feature of mammalian adaptive immunity is the highly diverse pool of antigen
receptors found on lymphocytes. The T-cell receptor and the surface immunoglobulin on B …