Objective To describe clinical and pathological characteristics and treatment outcomes in a
large cohort of aggressive pituitary tumours (APT)/pituitary carcinomas (PC). Design …

Aggressive pituitary tumors (APTs) and pituitary carcinomas (PCs) are heterogeneous with
regard to clinical presentation, proliferative markers, clinical course, and response to …

Objective To collect outcome data in a large cohort of patients with aggressive pituitary
tumours (APT)/carcinomas (PC) and specifically report effects of temozolomide (TMZ) …

Abstract The European Society of Endocrinology (ESE) survey reported on the largest cohort
of 125 aggressive pituitary tumours (APT) and 40 pituitary carcinomas (PC). Whilst the …

Pituitary adenohypophyseal tumors are considered as benign and termed “adenomas”.
However, many tumors are invasive and a proportion of these exhibit an “aggressive …

Background Pituitary carcinoma (PC) is an aggressive neuroendocrine tumor diagnosed
when a pituitary adenoma (PA) becomes metastatic. PCs are typically resistant to therapy …

Pituitary adenomas are unique in multiple ways. They are rarely malignant in terms of
metastases; yet, they may be aggressive. Their cancerous potential is defined in a classic …

Background Pituitary tumours are common and easily treated by surgery or medical
treatment in most cases. However, a small subset of pituitary tumours does not respond to …

Pituitary adenomas are common intracranial tumors that are mainly considered as benign.
Rarely, these tumors can exhibit an aggressive behavior, characterized by gross invasion of …

Although usually benign, anterior pituitary tumours occasionally exhibit aggressive
behaviour, with invasion of surrounding tissues, rapid growth, resistance to conventional …