Tailoring of corticosteroids in COPD management

DA De Coster, M Jones - Current respiratory care reports, 2014 - Springer
This literature review updates the reader on the new studies regarding steroid therapy over
the last year in stable COPD and in exacerbations. In stable COPD, we critique the 2011 …

New insights into the optimal management of COPD: extracts from CHEST 2021 annual meeting (October 17–20, 2021)

J Quint, J Montonen, D Singh, H Wachtel… - Expert Review of …, 2022 - Taylor & Francis
Introduction Discordance between real-world prescribing patterns and global treatment
guidelines for the treatment of chronic obstructive pulmonary disease (COPD) with inhaled …

Reassessing the role of eosinophils as a biomarker in chronic obstructive pulmonary disease

M Tinè, D Biondini, U Semenzato, E Bazzan… - Journal of clinical …, 2019 - mdpi.com
Blood eosinophils measurement, as proxy for tissue eosinophils, has become an important
biomarker for exacerbation risk and response to inhaled corticosteroids (ICS) in Chronic …

Stability of the blood eosinophilic phenotype in stable and exacerbated COPD

DM Schumann, M Tamm, K Kostikas, D Stolz - Chest, 2019 - Elsevier
Background There is controversy regarding the use of blood eosinophil levels as a
biomarker of exacerbation risk and responsiveness of patients to inhaled corticosteroids …

Inhaled corticosteroids in COPD: the clinical evidence

P Ernst, N Saad, S Suissa - European Respiratory Journal, 2015 - Eur Respiratory Soc
In this article, we focus on the scientific evidence from randomised trials supporting
treatment with inhaled corticosteroids (ICS) in chronic obstructive pulmonary disease …

Progression of chronic obstructive pulmonary disease: impact of inflammation, comorbidities and therapeutic intervention

RA Stockley - Current medical research and opinion, 2009 - Taylor & Francis
Background and aim: Chronic obstructive pulmonary disease (COPD) is a major cause of
morbidity and mortality, and through under-diagnosis, is often inappropriately treated. This …

Blood eosinophil guided prednisolone therapy for exacerbations of COPD: a further analysis

M Bafadhel, L Davies, PMA Calverley… - European …, 2014 - Eur Respiratory Soc
Exacerbations of chronic obstructive pulmonary disease (COPD) are associated with
significant morbidity and mortality [ 1]. Current guidelines advocate the use of systemic …

[HTML][HTML] Tackling COPD: a multicomponent disease driven by inflammation

P Kardos, J Keenan - Medscape General Medicine, 2006 - ncbi.nlm.nih.gov
In recent years, research has revealed more about the factors underlying the pathogenesis
of chronic obstructive pulmonary disease (COPD). In particular, inflammation in the lungs …

Escalation and de-escalation of therapy in COPD: myths, realities and perspectives

M Cazzola, P Rogliani, MG Matera - Drugs, 2015 - Springer
Chronic obstructive pulmonary disease (COPD) guidelines and strategies suggest
escalating treatment, mainly depending on the severity of airflow obstruction. However …

[HTML][HTML] Response to various biologics in patients with both asthma and chronic obstructive pulmonary disease

M Lommatzsch, SN Mohme, P Stoll, JC Virchow - Respiration, 2023 - karger.com
Introduction: Patients can have features of both chronic obstructive pulmonary disease
(COPD) and asthma. However, there is still no consensus how to precisely define this …