[PDF][PDF] The PD-1 pathway regulates development and function of memory CD8+ T cells following respiratory viral infection
The PD-1 pathway regulates dysfunctional T cells in chronic infection and cancer, but the
role of this pathway during acute infection remains less clear. Here, we demonstrate that PD …
role of this pathway during acute infection remains less clear. Here, we demonstrate that PD …
Metabolic regulation by PD-1 signaling promotes long-lived quiescent CD8 T cell memory in mice
Inhibitory signaling in dysfunctional CD8 T cells through the programmed cell death 1 (PD-1)
axis is well established in chronic viral infections and cancers. PD-1 is also transiently …
axis is well established in chronic viral infections and cancers. PD-1 is also transiently …
Programmed death 1 regulates development of central memory CD8 T cells after acute viral infection
SR Allie, W Zhang, S Fuse… - The Journal of …, 2011 - journals.aai.org
The T cell response possesses a number of inhibitory receptors to regulate the extent of the
antiviral response and prevent immune pathology. These receptors are generally transiently …
antiviral response and prevent immune pathology. These receptors are generally transiently …
[HTML][HTML] Viral acute lower respiratory infections impair CD8+ T cells through PD-1
JJ Erickson, P Gilchuk, AK Hastings… - The Journal of …, 2012 - Am Soc Clin Investig
Viruses are leading causes of severe acute lower respiratory infections (LRIs). These
infections evoke incomplete immunity, as individuals can be repeatedly reinfected …
infections evoke incomplete immunity, as individuals can be repeatedly reinfected …
Tissue-specific differences in PD-1 and PD-L1 expression during chronic viral infection: implications for CD8 T-cell exhaustion
SD Blackburn, A Crawford, H Shin, A Polley… - Journal of …, 2010 - Am Soc Microbiol
ABSTRACT The PD-1/PD-L pathway plays a major role in regulating T-cell exhaustion
during chronic viral infections in animal models, as well as in humans, and blockade of this …
during chronic viral infections in animal models, as well as in humans, and blockade of this …
PD-1 upregulated on regulatory T cells during chronic virus infection enhances the suppression of CD8+ T cell immune response via the interaction with PD-L1 …
Regulatory T (T reg) cells act as terminators of T cell immuniy during acute phase of viral
infection; however, their role and suppressive mechanism in chronic viral infection are not …
infection; however, their role and suppressive mechanism in chronic viral infection are not …
Role of PD-1 in regulating acute infections
KE Brown, GJ Freeman, EJ Wherry… - Current opinion in …, 2010 - Elsevier
While the role of PD-1 in inhibiting immunity during chronic infections is well established, its
functions during acute infections are much less clear. The PD-1 pathway can dampen CD8 T …
functions during acute infections are much less clear. The PD-1 pathway can dampen CD8 T …
PD-1 ligands, negative regulators for activation of naive, memory, and recently activated human CD4+ T cells
G Cai, A Karni, EML Oliveira, HL Weiner, DA Hafler… - Cellular …, 2004 - Elsevier
We examined the role of the PD-1 pathway on the activation of naïve, memory, and recently
activated human CD4+ T cells to test whether they responded differently. PD-1 ligand …
activated human CD4+ T cells to test whether they responded differently. PD-1 ligand …
PD-1hi CD8+ resident memory T cells balance immunity and fibrotic sequelae
CD8+ tissue-resident memory T (TRM) cells provide frontline immunity in mucosal tissues.
The mechanisms regulating CD8+ TRM maintenance, heterogeneity, and protective and …
The mechanisms regulating CD8+ TRM maintenance, heterogeneity, and protective and …
Activation drives PD‐1 expression during vaccine‐specific proliferation and following lentiviral infection in macaques
DA Hokey, FB Johnson, J Smith… - European journal of …, 2008 - Wiley Online Library
Recent data supports that increased expression of PD‐1, a negative regulator of immune
function, is associated with T cell exhaustion during chronic viral infection. However, PD‐1 …
function, is associated with T cell exhaustion during chronic viral infection. However, PD‐1 …