Background Type 2 diabetes mellitus (T2DM), one of the global health issues, is a group of
metabolic diseases and is affected by several genetic loci in the clinical phenotype. This …

Background Type 2 diabetes mellitus (T2DM) is caused by diverse environmental and
genetic risk factors. Previous studies have reported that cytochrome P450 (CYP) is a …

Abstract Background Cytochrome P450 (CYPs) participate in the mechanisms of
cardiovascular disease. The purpose of this research was to evaluate the contributions of …

Background Coronary heart disease (CHD) is a disease that seriously harms human health.
Genetic factors seriously affect the CHD susceptibility. The CYP20A1, CYP4F2 and CYP2D6 …

The previous study has pointed to that endogenous CYP metabolites play an important role
in the pathogenesis of coronary heart disease (CHD). The study aimed to identify the …

Background Coronary heart disease (CHD) has become a worldwide public health problem.
Genetic factors are considered important risk factors for CHD. The aim of this study was to …

Although several environmental factors, including a high-calorie diet and physical inactivity,
influence the development of type 2 diabetes mellitus, genetic factors have been shown to …

Background: Cytochrome P450s (CYPs) are drug-metabolizing enzymes catalyzing the
metabolism of about 75% of drug in clinical use. CYP2C9 represents 20% CYP proteins in …

Using a case–control design, we assessed the association between single nucleotide
polymorphisms of CYP3A4 gene rs4646437 polymorphism and the risk of hypertension in …

Background The cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) gene is
expressed in the vascular endothelium, which metabolizes arachidonic acid into 20 …