BACKGROUND: Amantadine, an aliphatic primary amine with complex actions on
neurotransmitter systems in the basal ganglia, is approved for treating Parkinson's disease …

INTRODUCTION Amantadine and anticholinergics have been used for several decades as
therapy for Parkinson's disease (PD). In spite of reduced interest in these compounds with …

Background Dyskinesias are some of the major motor complications that impair quality of life
for patients with Parkinson's disease. The purpose of the present study was to investigate …

Evaluation of: Wolf E, Seppi K, Katzenschlager R et al. Long-term antidyskinetic efficacy of
amantadine in Parkinson's disease. Mov. Disord. DOI: 10.1002/mds. 23034 (2010)(Epub …

Background: Recent short-term studies suggested that amantadine (Ama) might ameliorate
dyskinesia in patients with Parkinson's disease. A double-blind study programmed over 12 …

Amantadine is frequently used in addition to dopaminergic substances like dopamine
agonists or L-Dopa in advanced Parkinson disease (PD). However, adverse effects like …

The aim of the current review was to provide a new, in-depth insight into possible
pharmacological targets of amantadine to pave the way to extending its therapeutic use to …

The usual adverse events of amantadine are dizziness, dry mouth, and peripheral edema.
Postmarketing experience has revealed abnormal movements such as tremors, involuntary …

Objectives: Identify the proper indications for amantadine therapy. Describe the mechanism
of action of amantadine. Review the potential adverse effects of amantadine. Outline the …

Purpose: Amantadine is commonly used to treat Parkinson's disease. A case of myoclonus
and asterixis was associated with amantadine is reported. Case Summary: An 80-year-old …