Objective To investigate whether patients with RA enrolled in randomized controlled trials
(RCTs) and observational studies may differ in terms of characteristics that could modify …

Objective: To conduct a cross-sectional review of non-selected consecutive outpatients with
rheumatoid arthritis (RA) as part of standard clinical care in 15 countries for an overview of …

Our aim was to establish the comparative effectiveness of rheumatoid arthritis (RA)
biologics, using a systematic review and network meta-analysis. The systematic review used …

Objectives Current guidelines rank abatacept, rituximab, tocilizumab and TNF-inhibitors
(TNFi) as having equal effectiveness for the treatment of RA, at least as second line …

Objective The approved dose of rituximab (RTX) for rheumatoid arthritis (RA) is 2× 1,000 mg
infusions given 2 weeks apart. There is contradictory evidence regarding the effectiveness of …

Background Tumour necrosis factor (TNF) inhibition and B-cell depletion are highly effective
treatments for active rheumatoid arthritis, but so far no randomised controlled trials have …

PURPOSE: Randomized controlled trials (RCTs) have demonstrated the efficacy of biologic
agents in the treatment of rheumatic diseases. However, results from RCTs may not be …

Background Aiming at therapeutic targets has reduced the risk of organ failure in many
diseases such as diabetes or hypertension. Such targets have not been defined for …

Abstract Background The Health Assessment Questionnaire-Disability Index (HAQ-DI) is
used to assess functional status in rheumatoid arthritis (RA), but the change required for …

Background We implemented a novel method for providing contextual adverse event rates
for a randomised controlled trial (RCT) programme through coordinated analyses of five RA …